Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]-

Base Information

• Chemical Name: Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]-
• CAS No.: 460747-00-6
• Molecular Formula: C16H15IN2O3
• Molecular Weight: 410.211
• Mol file: 460747-00-6.mol

Synonyms:

Chemical Property of Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]-

There total 7 articles about Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-[5-(4-morpholinylcarbonyl)-1,6-dihydro-2-pyridinyl]phenol + sodium thiosulfate → 2-iodo-4-[5-(4-morpholinylcarbonyl)-2-pyridinyl]phenol (460747-00-6)

Guidance literature:

With sodium hydroxide; sodium hypochlorite; sodium iodide; sodium iodide; In methanol; water;

Reference yield: 61.0%

[6-(4-hydroxy-phenyl)-pyridin-3-yl]-morpholin-4-yl-methanone (477740-54-8) → 2-iodo-4-[5-(4-morpholinylcarbonyl)-2-pyridinyl]phenol (460747-00-6)

Guidance literature:

With sodium hypochlorite; sodium iodide; In methanol; at 0 ℃;

DOI:10.1016/j.bmcl.2003.11.032

Reference yield:

4-[(6-chloro-3-pyridinyl)carbonyl]morpholine (64614-49-9) → 2-iodo-4-[5-(4-morpholinylcarbonyl)-2-pyridinyl]phenol (460747-00-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / Pd(Ph₃P)4; aq. Na₂CO₃ / toluene / Heating

2: 93 percent / TBAF

3: 61 percent / sodium iodide; sodium hypochlorite / methanol / 0 °C

With sodium hypochlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium carbonate; sodium iodide; In methanol; toluene; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2003.11.032

upstream raw materials:

[6-(4-hydroxy-phenyl)-pyridin-3-yl]-morpholin-4-yl-methanone

4-[(6-chloro-3-pyridinyl)carbonyl]morpholine

6-Chloronicotinoyl chloride

t-butyldimethylsilyl-4-bromophenol