7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile

Base Information

• Chemical Name: 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile
• CAS No.: 938465-55-5
• Molecular Formula: C₂₀H₁₄BrN₃OS
• Molecular Weight: 424.321
• Mol file: 938465-55-5.mol

Synonyms:7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile

Chemical Property of 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile

There total 1 articles about 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-1,8-dichloro[1]benzothieno[3,2-c]pyridine + 4-methoxy-benzylamine (2393-23-9) → 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile (938465-55-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 1h;

Reference yield:

methanol (67-56-1) + 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile (938465-55-5) + carbon monoxide (201230-82-2) → methyl 4-cyano-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-7-carboxylate (1132650-44-2)

Guidance literature:

With sodium acetate; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; for 18h; under 9034.64 Torr;

Reference yield:

7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile (938465-55-5) + 4-trifluoromethylphenylboronic acid (128796-39-4) → (E)-2-(4-fluorophenyl)vinylboronic acid (460748-43-0)

Guidance literature:

With sodium carbonate; triphenylphosphine; palladium diacetate; In propan-1-ol; water; at 100 ℃; for 3h;

upstream raw materials:

4-methoxy-benzylamine

Downstream raw materials:

methyl 4-cyano-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-7-carboxylate

(E)-2-(4-fluorophenyl)vinylboronic acid

1-[(4-methoxybenzyl)amino]-7-[4-(trifluoromethyl)phenyl][1]benzothieno[3,2-c]pyridine-4-carbonitrile

1-[(4-methoxybenzyl)amino]-7-[4-(methylsulfonyl)phenyl][1]benzothieno[3,2-c]pyridine-4-carbonitrile