2H-Thiopyran-4-methanol, tetrahydro-, 1,1-dioxide

Base Information

• Chemical Name: 2H-Thiopyran-4-methanol, tetrahydro-, 1,1-dioxide
• CAS No.: 473254-28-3
• Molecular Formula: C6H12O3S
• Molecular Weight: 164.225
• Hs Code.: 2932990090
• Mol file: 473254-28-3.mol

Synonyms:4-hydroxymethyl-2-pyridinecarboxamide;(1',1'-dioxo-hexahydro-1-thiopyran-4-yl)methanol;2-Pyridinecarboxamide,4-(hydroxymethyl);(1,1-dioxo-tetrahydro-2H-thiopyran-4-yl)methanol;2-Carbamoylpyridine-4-methanol;4-(hydroxymethyl)tetrahydro-2H-thiopyran 1,1-dioxide;

Chemical Property of 2H-Thiopyran-4-methanol, tetrahydro-, 1,1-dioxide

Chemical Property:

• Boiling Point: 376.1±15.0 °C(Predicted)
• PKA: 14.66±0.10(Predicted)
• PSA: 62.75000
• Density: 1.247±0.06 g/cm3(Predicted)
• LogP: 0.88430

Purity/Quality:

97% ^*data from raw suppliers

Tetrahydro-2H-thiopyran-4-methanol1,1-Dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Thiopyran-4-methanol, tetrahydro-, 1,1-dioxide

There total 9 articles about 2H-Thiopyran-4-methanol, tetrahydro-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(tetrahydro-2H-thiopyran-4-yl)methanol (100277-27-8) → (1,1-dioxo-hexahydro-1-thiopyran-4-yl)-methanol (473254-28-3)

Guidance literature:

With sodium periodate; In methanol; water; at 20 - 50 ℃; for 60h;

DOI:10.1021/acs.jmedchem.5b00773

Reference yield: 86.0%

1,1-dioxo-hexahydro-1λ6-thiopyran-4-carboxylic acid (64096-87-3) → (1,1-dioxo-hexahydro-1-thiopyran-4-yl)-methanol (473254-28-3)

Guidance literature:

With dimethylsulfide borane complex; In dichloromethane; at 37 ℃; for 2h; Inert atmosphere;

DOI:10.1021/op800108s

Reference yield:

methyl tetrahydro-2H-thiopyran-4-carboxylate-1,1-dioxide (917807-18-2) → (1,1-dioxo-hexahydro-1-thiopyran-4-yl)-methanol (473254-28-3)

Guidance literature:

methyl tetrahydro-2H-thiopyran-4-carboxylate-1,1-dioxide; With lithium borohydride; In tetrahydrofuran; at 40 ℃; Cooling with ice;

With water; In tetrahydrofuran; Cooling with ice;

upstream raw materials:

(tetrahydro-2H-thiopyran-4-yl)methanol

methyl tetrahydro-2H-thiopyran-4-carboxylate-1,1-dioxide

Tetrahydrothiopyran-4-one

tetrahydro-2H-thiopyran-4-carboxylic acid

Downstream raw materials:

(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methyl 4-methylbenzenesulfonate

ethyl 2-(3-(4-((4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate

2-(3-(4-((4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid

ethyl 2-(3-(4-((2'-chloro-4'-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate