64096-87-3

Usage

Uses

Used in Organic Synthesis:
1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure and functional groups allow for a wide range of chemical reactions, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid is used as a starting material or a synthetic intermediate for the development of new drugs. Its carboxylic acid and cyclic ester groups can be modified to create novel drug candidates with potential therapeutic applications.
Used in Materials Science:
1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid is utilized in materials science for the development of new materials with unique properties. Its ability to form stable structures and participate in various chemical reactions makes it a promising candidate for the creation of advanced materials with applications in coatings, adhesives, and other industrial products.
Used in Chemical Engineering:
In chemical engineering, 1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid is employed in the design and optimization of chemical processes. Its properties and reactivity can be harnessed to improve the efficiency and selectivity of chemical reactions, leading to the development of more sustainable and cost-effective processes in the chemical industry.

Upstream product

• 89489-53-2 tetrahydro-2H-thiopyran-4-carboxylic acid 
• 77-77-0 Divinyl sulfone 
• 2033-24-1 cycl-isopropylidene malonate 
• 917807-18-2 methyl tetrahydro-2H-thiopyran-4-carboxylate-1,1-dioxide 
• 1028854-35-4 1,1-dioxo-tetrahydro-1λ6-thiopyran-4,4-dicarboxylic acid 
• 64096-86-2 3,3-dimethyl-2,4-dioxa-9-thiaspiro[5.5]undecane-1,5-dione-9,9-dioxide 
• 128094-82-6 tetrahydro-thiopyran-4-carboxylic acid methyl ester 
• 195503-40-3 tetrahydro-2H-thiopyrane-4-carbonitrile 

Downstream Products

• 841301-32-4 N-(2-((4-(1,2,4-oxadiazol-3-yl)phenyl)amino)-2-oxoethyl)-N-(2,6-dimethylphenyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide 
• 625117-31-9 N-(2,6-dimethylphenyl)-N-(1,1-dioxohexahydropyran-4-formyl)glycine ethyl ester 
• 473254-30-7 4-acetyl-1λ6-thiane-1,1-dione 
• 494210-61-6 1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carbaldehyde 

Relevant academic research and scientific papers

NEW PROCESS FOR THE PREPARATION OF AMENAMEVIR

The present invention relates to an improved process for the preparation of Amenamevir and derivatives thereof via a four component Ugi reaction.

METHOD FOR PRODUCING 1,1-DIOXO-HEXAHYDRO-THIOPYRAN-4-CARBOXYLIC ACID OR DERIVATIVE THEREOF

PROBLEM TO BE SOLVED: To provide a practical and efficient method for producing 1,1-dioxo-hexahydro-thiopyran-4-carboxylic acid or a derivative thereof in an industrial scale. SOLUTION: Provided ia a method for producing 1,1-dioxo-hexahydro-thiopyran-4-carboxylic acid represented by the following formula or a derivative thereof, comprising: (step 1) a step of mesylating two hydroxy groups of di(2-hydroxyethyl) sulfone; (step 2) a step of condensing the dimesylated body with meldrum acid to obtain 3,3-dimethyl-9,9-dioxo-2,4-dioxa-9-thiaspiro[5.5]undecane-1,5-dione; and (step 3) a step of hydrolyzing and decarbonating the aforementioned compound to obtain 1,1-dioxo-hexahydro-thiopyran-4-carboxylic acid. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Compounds Which Modulate The CB2 Receptor

Compounds of formula (I) are disclosed. Compounds according to the and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

HETEROCYCLIC COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR

Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

A practical, efficient synthesis of 1,1-dioxo-hexahydro-1#-thiopyran-4- carbaldehyde

A practical, efficient, and scalable procedure for the preparation of l,1-dioxo-hexahydro-1λ6-thiopyran-4-carbaldehyde is reported. Synthesis of this aldehyde was complicated by high aqueous solubility of the product and the intermediates. The isolation and purification of the aldehyde was accomplished by conversion to the crystalline bisulfite adduct.

TRIAZOLYLPIPERIDINE DERIVATIVES AND USE THEREOF IN THERAPY

The present invention provides compounds of formula (I) Wherein R1 , R2, R3 , R4 , Het and m are as defined in the description. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors.

FUSED HETEROCYCLIC COMPOUNDS

Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.