9H-Purine-9-ethanol,6-amino-b-[1-(hydroxymethyl)-2-(triphenylmethoxy)ethoxy]-,a-(4-methylbenzenesulfonate),[S-(R,S)]- (9CI)

Base Information

Chemical Name:9H-Purine-9-ethanol,6-amino-b-[1-(hydroxymethyl)-2-(triphenylmethoxy)ethoxy]-,a-(4-methylbenzenesulfonate),[S-(R*,S*)]- (9CI)
CAS No.:104532-14-1
Molecular Formula:C36H35 N5 O6 S
Molecular Weight:391.2307
Hs Code.:
Mol file:104532-14-1.mol

Synonyms:

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Chemical Property of 9H-Purine-9-ethanol,6-amino-b-[1-(hydroxymethyl)-2-(triphenylmethoxy)ethoxy]-,a-(4-methylbenzenesulfonate),[S-(R*,S*)]- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 9H-Purine-9-ethanol,6-amino-b-[1-(hydroxymethyl)-2-(triphenylmethoxy)ethoxy]-,a-(4-methylbenzenesulfonate),[S-(R*,S*)]- (9CI)

There total 3 articles about 9H-Purine-9-ethanol,6-amino-b-[1-(hydroxymethyl)-2-(triphenylmethoxy)ethoxy]-,a-(4-methylbenzenesulfonate),[S-(R*,S*)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 98-59-9
p-toluenesulfonyl chloride

: 104532-12-9
5'-O-(triphenylmethyl)-2',3'-secoadenosine

: 104532-15-2
3'-O-p-toluenesulfonyl-5'-O-(triphenylmethyl)-2',3'-secoadenosine

: 104532-14-1
2'-O-p-toluenesulfonyl-5'-O-(triphenylmethyl)-2',3'-secoadenosine

Guidance literature:: With pyridine; for 6h;
DOI:10.1021/jm00162a005

Reference yield:

: 18048-85-6
5'-O-(triphenylmethyl)adenosine

: 104532-14-1
2'-O-p-toluenesulfonyl-5'-O-(triphenylmethyl)-2',3'-secoadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 9.9 g / sodium periodate / methanol; H₂O / 20 h / Ambient temperature

2: 87 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

3: 25 percent / pyridine / 6 h

With pyridine; sodium tetrahydroborate; sodium periodate; In methanol; ethanol; water;
DOI:10.1021/jm00162a005

Reference yield:

: 104532-11-8
(R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde

: 104532-14-1
2'-O-p-toluenesulfonyl-5'-O-(triphenylmethyl)-2',3'-secoadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

2: 25 percent / pyridine / 6 h

With pyridine; sodium tetrahydroborate; In ethanol;
DOI:10.1021/jm00162a005