(R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde

Base Information

• Chemical Name: (R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde
• CAS No.: 104532-11-8
• Molecular Formula: C₂₉H₂₅N₅O₄
• Molecular Weight: 507.549
• Mol file: 104532-11-8.mol

Synonyms:(R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde

Chemical Property of (R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde

There total 1 articles about (R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(triphenylmethyl)adenosine (18048-85-6) → (R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde (104532-11-8)

Guidance literature:

With sodium periodate; In methanol; water; for 20h; Ambient temperature;

DOI:10.1021/jm00162a005

Reference yield: 87.0%

(R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde (104532-11-8) → 5'-O-(triphenylmethyl)-2',3'-secoadenosine (104532-12-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 2h; Ambient temperature;

DOI:10.1021/jm00162a005

Reference yield:

(R)-2-[(R)-1-(6-Amino-purin-9-yl)-2-oxo-ethoxy]-3-trityloxy-propionaldehyde (104532-11-8) → 9-<6(S)-<(triphenylmethoxy)methyl>-1,4-dioxacyclohexan-2(R)-yl>adenine (104532-16-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

2: 22 percent / pyridine / 6 h

3: 75 percent / 1 N sodium methoxide / methanol / 2.5 h / 60 °C

With pyridine; sodium tetrahydroborate; sodium methylate; In methanol; ethanol;

DOI:10.1021/jm00162a005

upstream raw materials:

5'-O-(triphenylmethyl)adenosine

Downstream raw materials:

5'-O-(triphenylmethyl)-2',3'-secoadenosine

2',3'-Dideoxy-2',3'-secoadenosin-1',2'-diene

9-<6(S)-(hydroxymethyl)-1,4-dioxacyclohexan-2(R)-yl>adenine

5'-O-(triphenylmethyl)-2',3'-dideoxy-2',3'-secoadenosine-1',3'-diene