Technology Process of Carbamic acid, [4-(1,1-dioxido-4-thiomorpholinyl)-3,5-difluorophenyl]-,
2-methylpropyl ester
There total 4 articles about Carbamic acid, [4-(1,1-dioxido-4-thiomorpholinyl)-3,5-difluorophenyl]-,
2-methylpropyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
tetrahydrofuran; water; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aluminum (III) chloride / toluene / 24 h / 110 °C / Large scale
2: nitric acid; acetic acid / 48 h / 20 - 30 °C / Large scale
3: hydrogen / ethanol; tetrahydrofuran / 40 °C / 2828.7 Torr / Autoclave; Large scale
4: potassium carbonate / tetrahydrofuran; water / 8 h / 45 - 55 °C / Large scale
With
aluminum (III) chloride; hydrogen; nitric acid; potassium carbonate; acetic acid;
In
tetrahydrofuran; ethanol; water; toluene;
1: |Michael Addition / 4: |Schotten-Baumann Reaction;
DOI:10.1021/op050207i
- Guidance literature:
-
Multi-step reaction with 3 steps
1: nitric acid; acetic acid / 48 h / 20 - 30 °C / Large scale
2: hydrogen / ethanol; tetrahydrofuran / 40 °C / 2828.7 Torr / Autoclave; Large scale
3: potassium carbonate / tetrahydrofuran; water / 8 h / 45 - 55 °C / Large scale
With
hydrogen; nitric acid; potassium carbonate; acetic acid;
In
tetrahydrofuran; ethanol; water;
3: |Schotten-Baumann Reaction;
DOI:10.1021/op050207i
