1,3-dihydro-3-ethyl-2H-indol-2-one

Base Information

• Chemical Name: 1,3-dihydro-3-ethyl-2H-indol-2-one
• CAS No.: 15379-45-0
• Molecular Formula: C10H11 N O
• Molecular Weight: 161.203
• Hs Code.: 2933790090
• Mol file: 15379-45-0.mol

Synonyms:2-Indolinone,3-ethyl- (7CI,8CI); Oxindole, 3-ethyl- (6CI); 3-Ethyl-1,3-dihydroindol-2-one;3-Ethyl-2-indolinone; 3-Ethyloxindole; NSC 405958

Chemical Property of 1,3-dihydro-3-ethyl-2H-indol-2-one

Chemical Property:

• Vapor Pressure: 0.0018mmHg at 25°C
• Boiling Point: 292.7°C at 760 mmHg
• Flash Point: 168.3°C
• PSA: 29.10000
• Density: 1.084g/cm³
• LogP: 2.27030

Purity/Quality:

99% ^*data from raw suppliers

3-ethyl-2,3-dihydro-1H-indol-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-dihydro-3-ethyl-2H-indol-2-one

There total 34 articles about 1,3-dihydro-3-ethyl-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

carbon monoxide (201230-82-2) + trans-β-methyl-o-aminostyrene (33149-71-2) → 3-ethyloxindole (15379-45-0)

Guidance literature:

With palladium diacetate; hydrogen; tricyclohexylphosphine; In dichloromethane; at 100 ℃; for 48h; under 31028.9 Torr;

DOI:10.1021/ja953403l

Reference yield: 98.0%

2-oxoindole (59-48-3) + ethanol (64-17-5) → 3-ethyloxindole (15379-45-0)

Guidance literature:

nickel; at 150 ℃; for 5h;

DOI:10.1055/s-2002-23544

Reference yield: 95.0%

ethanol (64-17-5) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 3-ethyloxindole (15379-45-0)

Guidance literature:

With hydrogen; at 180 ℃; under 11251.1 Torr;

DOI:10.1021/acs.jmedchem.5b00095

upstream raw materials:

2-oxoindole

ethanol

spiro[[1,3]dithiolane-2,3'-indolin]-2'-one

butyric acid N'-phenyl-hydrazide

Downstream raw materials:

1-diphenylacetyl-3-ethyloxindole