Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-(methoxymethoxy)phenyl ester

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Chemical Name:Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-(methoxymethoxy)phenyl ester
CAS No.:474295-96-0
Molecular Formula:C25H33N3O9
Molecular Weight:519.552
Hs Code.:
Mol file:474295-96-0.mol

Synonyms:

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Chemical Property of Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-(methoxymethoxy)phenyl ester

Chemical Property:

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Technology Process of Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-(methoxymethoxy)phenyl ester

There total 3 articles about Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-(methoxymethoxy)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 444646-81-5
[1-(4-dimethylcarbamoyloxy-2-methoxymethoxyphenyl)-3-hydroxypropyl]carbamic acid tert-butyl ester

: 474295-96-0
[1-(4-dimethylcarbamoyloxy-2-methoxymethoxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 444646-79-1
3-tert-butoxycarbonylamino-3-(4-hydroxy-2-methoxymethoxyphenyl)propionic acid ethyl ester

: 474295-96-0
[1-(4-dimethylcarbamoyloxy-2-methoxymethoxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / K₂CO₃ / dimethylformamide / 3 h / 20 °C

2: 82 percent / LiAlH₄ / tetrahydrofuran / 0.42 h / -50 - 0 °C

3: 6.49 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 3: Mitsunobu reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 444646-80-4
ethyl (3R)-t-butoxycarbonylamino-(3R)-(4-dimethylcarbamoyloxy-2-methoxymethoxy-phenyl)-propionate

: 474295-96-0
[1-(4-dimethylcarbamoyloxy-2-methoxymethoxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / LiAlH₄ / tetrahydrofuran / 0.42 h / -50 - 0 °C

2: 6.49 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

With lithium aluminium tetrahydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; 2: Mitsunobu reaction;
DOI:10.1016/S0968-0896(03)00452-8