Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-ethenylphenyl ester

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Chemical Name:Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-ethenylphenyl ester
CAS No.:474295-98-2
Molecular Formula:C25H31N3O7
Molecular Weight:485.537
Hs Code.:
Mol file:474295-98-2.mol

Synonyms:

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Chemical Property of Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-ethenylphenyl ester

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Technology Process of Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-ethenylphenyl ester

There total 7 articles about Carbamic acid, dimethyl-, 4-[(1R)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-nitrophenoxy)prop yl]-3-ethenylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 7486-35-3
tri-n-butyl(vinyl)tin

: 474296-05-4
trifluoro-methanesulfonic acid 2-[1-tert-butoxycarbonylamino-3-(4-nitro-phenoxy)-propyl]-5-dimethylcarbamoyloxy-phenyl ester

: 474295-98-2
[1-(4-dimethylcarbamoyloxy-2-vinyl-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; lithium chloride; In 1,4-dioxane; at 100 ℃; for 2h;
DOI:10.1021/ol026418e

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 474295-98-2
[1-(4-dimethylcarbamoyloxy-2-vinyl-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 6.49 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

2: 1.91 g / hydrochloric acid / methanol / 18 h / 20 °C

3: 85 percent / triethylamine / methanol / 1 h / 20 °C

4: 1.89 g / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

5: 1.47 g / Pd(PPh₃)4; LiCl; 2,6-di-t-butylphenol / dioxane / 2 h / 100 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; triethylamine; triphenylphosphine; lithium chloride; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; 1: Mitsunobu reaction / 5: Stille reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 474295-97-1
[1-(4-dimethylcarbamoyloxy-2-hydroxyphenyl)-3-(4-nitrophenoxy)propyl]carbamic acid tert-butyl ester

: 474295-98-2
[1-(4-dimethylcarbamoyloxy-2-vinyl-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.89 g / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

2: 1.47 g / Pd(PPh₃)4; LiCl; 2,6-di-t-butylphenol / dioxane / 2 h / 100 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; lithium chloride; In 1,4-dioxane; dichloromethane; 2: Stille reaction;
DOI:10.1016/S0968-0896(03)00452-8