2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -, 1,1-dimethylethyl ester, (1R)-

Base Information

Chemical Name:2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -, 1,1-dimethylethyl ester, (1R)-
CAS No.:474296-00-9
Molecular Formula:C26H31N3O7
Molecular Weight:497.548
Hs Code.:
Mol file:474296-00-9.mol

2H-2-Benzazepine-2-carboxylic acid,
7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl]
-, 1,1-dimethylethyl ester, (1R)-

Synonyms:

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Chemical Property of 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -, 1,1-dimethylethyl ester, (1R)-

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Technology Process of 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -, 1,1-dimethylethyl ester, (1R)-

There total 9 articles about 2H-2-Benzazepine-2-carboxylic acid, 7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-nitrophenoxy)ethyl] -, 1,1-dimethylethyl ester, (1R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 474295-99-3
allyl[1-(4-dimethylcarbamoyloxy-2-vinylphenyl)-3-(4-nitrophenoxy)propyl]carbamic acid tert-butyl ester

: 474296-00-9
7-dimethylcarbamoyloxy-1-[2-(4-nitro-phenoxy)-ethyl]-1,3-dihydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 45 ℃; for 3h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 474295-97-1
[1-(4-dimethylcarbamoyloxy-2-hydroxyphenyl)-3-(4-nitrophenoxy)propyl]carbamic acid tert-butyl ester

: 474296-00-9
7-dimethylcarbamoyloxy-1-[2-(4-nitro-phenoxy)-ethyl]-1,3-dihydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.89 g / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

2: 1.47 g / Pd(PPh₃)4; LiCl; 2,6-di-t-butylphenol / dioxane / 2 h / 100 °C

3: 86 percent / NaH / dimethylformamide / 4 h / 0 - 20 °C

4: 96 percent / (1,3-dimesitylimidazolidin-2-yl)[P(c-hexyl)3]Ru(=CHPh)Cl₂ / CH₂Cl₂ / 3 h / 45 °C

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; sodium hydride; lithium chloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 2: Stille reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 474295-96-0
[1-(4-dimethylcarbamoyloxy-2-methoxymethoxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 474296-00-9
7-dimethylcarbamoyloxy-1-[2-(4-nitro-phenoxy)-ethyl]-1,3-dihydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.91 g / hydrochloric acid / methanol / 18 h / 20 °C

2: 85 percent / triethylamine / methanol / 1 h / 20 °C

3: 1.89 g / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

4: 1.47 g / Pd(PPh₃)4; LiCl; 2,6-di-t-butylphenol / dioxane / 2 h / 100 °C

5: 86 percent / NaH / dimethylformamide / 4 h / 0 - 20 °C

6: 96 percent / (1,3-dimesitylimidazolidin-2-yl)[P(c-hexyl)3]Ru(=CHPh)Cl₂ / CH₂Cl₂ / 3 h / 45 °C

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; sodium hydride; triethylamine; lithium chloride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 4: Stille reaction;
DOI:10.1016/S0968-0896(03)00452-8