Methanesulfonic acid, trifluoro-, 5-[[(dimethylamino)carbonyl]oxy]-2-[(1R)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-3-(4-nitrophenoxy)propyl]phenyl ester

Base Information

Chemical Name:Methanesulfonic acid, trifluoro-, 5-[[(dimethylamino)carbonyl]oxy]-2-[(1R)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-3-(4-nitrophenoxy)propyl]phenyl ester
CAS No.:474296-05-4
Molecular Formula:C24H28F3N3O10S
Molecular Weight:607.562
Hs Code.:
Mol file:474296-05-4.mol

Methanesulfonic acid, trifluoro-,
5-[[(dimethylamino)carbonyl]oxy]-2-[(1R)-1-[[(1,1-dimethylethoxy)carbon
yl]amino]-3-(4-nitrophenoxy)propyl]phenyl ester

Synonyms:

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Chemical Property of Methanesulfonic acid, trifluoro-, 5-[[(dimethylamino)carbonyl]oxy]-2-[(1R)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-3-(4-nitrophenoxy)propyl]phenyl ester

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Technology Process of Methanesulfonic acid, trifluoro-, 5-[[(dimethylamino)carbonyl]oxy]-2-[(1R)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-3-(4-nitrophenoxy)propyl]phenyl ester

There total 6 articles about Methanesulfonic acid, trifluoro-, 5-[[(dimethylamino)carbonyl]oxy]-2-[(1R)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-3-(4-nitrophenoxy)propyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 474295-97-1
[1-(4-dimethylcarbamoyloxy-2-hydroxyphenyl)-3-(4-nitrophenoxy)propyl]carbamic acid tert-butyl ester

: 474296-05-4
trifluoro-methanesulfonic acid 2-[1-tert-butoxycarbonylamino-3-(4-nitro-phenoxy)-propyl]-5-dimethylcarbamoyloxy-phenyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1021/ol026418e DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 474296-05-4
trifluoro-methanesulfonic acid 2-[1-tert-butoxycarbonylamino-3-(4-nitro-phenoxy)-propyl]-5-dimethylcarbamoyloxy-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 6.49 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

2: 1.91 g / hydrochloric acid / methanol / 18 h / 20 °C

3: 85 percent / triethylamine / methanol / 1 h / 20 °C

4: 1.89 g / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

With pyridine; hydrogenchloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: Mitsunobu reaction;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 474295-96-0
[1-(4-dimethylcarbamoyloxy-2-methoxymethoxy-phenyl)-3-(4-nitro-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 474296-05-4
trifluoro-methanesulfonic acid 2-[1-tert-butoxycarbonylamino-3-(4-nitro-phenoxy)-propyl]-5-dimethylcarbamoyloxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.91 g / hydrochloric acid / methanol / 18 h / 20 °C

2: 85 percent / triethylamine / methanol / 1 h / 20 °C

3: 1.89 g / pyridine / CH₂Cl₂ / 0.17 h / 0 °C

With pyridine; hydrogenchloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(03)00452-8