Pyrazolo[1,5-a]pyridin-7-amine, N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)- 6-(triethoxymethyl)-

Base Information

Chemical Name:Pyrazolo[1,5-a]pyridin-7-amine, N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)- 6-(triethoxymethyl)-
CAS No.:474304-05-7
Molecular Formula:C34H43FN6O3
Molecular Weight:602.752
Hs Code.:
Mol file:474304-05-7.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrazolo[1,5-a]pyridin-7-amine, N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)- 6-(triethoxymethyl)-

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Technology Process of Pyrazolo[1,5-a]pyridin-7-amine, N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)- 6-(triethoxymethyl)-

There total 7 articles about Pyrazolo[1,5-a]pyridin-7-amine, N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)- 6-(triethoxymethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 468063-27-6
4-[7-chloro-2-(4-fluorophenyl)-6-(triethoxymethyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine

: 1003-03-8
Cyclopentamine

: 474304-05-7
N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-6-(triethoxymethyl)pyrazolo[1,5-a]pyridin-7-amine

Guidance literature:: at 80 ℃; for 16h;
DOI:10.1016/j.bmc.2005.09.015

Reference yield:

: 372122-55-9
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

: 474304-05-7
N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-6-(triethoxymethyl)pyrazolo[1,5-a]pyridin-7-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 94 percent / phosphorus oxychloride / 72 h / 20 °C

2.1: 96 percent / tetrahydrofuran / 14 h / 20 °C

3.1: 69 percent / manganese dioxide / CHCl₃ / 1.5 h / 0 °C

4.1: 98 percent / sodium ethoxide / ethanol / 15.5 h / 0 - 20 °C

5.1: sodium / 20 °C

5.2: 92 percent / ethanol / 18 h / 60 °C

6.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 46 percent / carbon tetrachloride / tetrahydrofuran; hexane / 2 h / 20 °C

7.1: 96 percent / 16 h / 80 °C

With manganese(IV) oxide; n-butyllithium; sodium ethanolate; sodium; diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; chloroform; 1.1: Vilsmeier-Haack formylation / 2.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.09.015

Reference yield:

: 468062-76-2
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde

: 474304-05-7
N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-6-(triethoxymethyl)pyrazolo[1,5-a]pyridin-7-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 96 percent / tetrahydrofuran / 14 h / 20 °C

2.1: 69 percent / manganese dioxide / CHCl₃ / 1.5 h / 0 °C

3.1: 98 percent / sodium ethoxide / ethanol / 15.5 h / 0 - 20 °C

4.1: sodium / 20 °C

4.2: 92 percent / ethanol / 18 h / 60 °C

5.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: 46 percent / carbon tetrachloride / tetrahydrofuran; hexane / 2 h / 20 °C

6.1: 96 percent / 16 h / 80 °C

With manganese(IV) oxide; n-butyllithium; sodium ethanolate; sodium; diisopropylamine; In tetrahydrofuran; ethanol; hexane; chloroform; 1.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.09.015