2-hydroxy-2,2-diphenylacetaldehyde

Base Information

• Chemical Name: 2-hydroxy-2,2-diphenylacetaldehyde
• CAS No.: 4746-86-5
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Mol file: 4746-86-5.mol

Synonyms:

Chemical Property of 2-hydroxy-2,2-diphenylacetaldehyde

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-2,2-diphenylacetaldehyde

There total 35 articles about 2-hydroxy-2,2-diphenylacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(diphenylhydroxymethyl)-1,3-oxathiane (94537-84-5) → hydroxy-diphenyl-acetaldehyde (4746-86-5)

Guidance literature:

With iodine; silver perchlorate; In tetrahydrofuran; water; for 0.166667h; Ambient temperature;

DOI:10.3987/com-96-s32

Reference yield: 92.0%

3,3-diphenyl-2-propenal (1210-39-5) → hydroxy-diphenyl-acetaldehyde (4746-86-5) + 2,2-diphenylvinyl formate (108787-96-8)

Guidance literature:

With 2-nitrobenzeneperoxyseleninic acid; In dichloromethane; for 13h; Ambient temperature;

DOI:10.1016/S0040-4020(01)89946-4

Reference yield: 89.0%

phenylmagnesium bromide (100-58-3) + Ethyl diethoxyacetate (6065-82-3) → hydroxy-diphenyl-acetaldehyde (4746-86-5)

Guidance literature:

phenylmagnesium bromide; Ethyl diethoxyacetate; In tetrahydrofuran; at 20 - 90 ℃; for 0.666667h; Inert atmosphere;

With hydrogenchloride; In water; acetone; at 70 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01205

upstream raw materials:

diethyl ether

2,2-dimethoxy-1-phenylethanone

2-bromo-2,2-diphenylethanal

hydroxy-diphenyl-acetaldehyde-semicarbazone

Downstream raw materials:

benzophenone

2-(2,5-dimethyl-phenyl)-1,1-diphenyl-ethane-1,2-diol

Benzilic acid

benzil