3',4',5',5,6,7-HEXAMETHOXYFLAVONE

Base Information

• Chemical Name: 3',4',5',5,6,7-HEXAMETHOXYFLAVONE
• CAS No.: 29043-07-0
• Molecular Formula: C21H22 O8
• Molecular Weight: 402.401
• Hs Code.: 2932999099
• Mol file: 29043-07-0.mol

Synonyms:Flavone,3',4',5,5',6,7-hexamethoxy- (8CI); 5,6,7,3',4',5'-Hexamethoxyflavone

Chemical Property of 3',4',5',5,6,7-HEXAMETHOXYFLAVONE

Chemical Property:

• Melting Point: 115oC
• Boiling Point: 572.8oC at 760 mmHg
• Flash Point: 249.9oC
• PSA: 85.59000
• Density: 1.244g/cm3
• LogP: 3.51160

Purity/Quality:

98%,99%, ^*data from raw suppliers

3'',4'',5'',5,6,7-Hexamethoxyflavone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',4',5',5,6,7-HEXAMETHOXYFLAVONE

There total 19 articles about 3',4',5',5,6,7-HEXAMETHOXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2’-hydroxy-3,4,4’,5,5’,6’-hexamethoxychalcone → 3',4',5,5',6,7-Hexamethoxyflavone (29043-07-0)

Guidance literature:

With sulfuric acid; In dimethyl sulfoxide; Heating;

DOI:10.1080/14786419.2021.1961136

Reference yield:

1-(6-hydroxy-2,3,4-trimethoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propane-1,3-dione (60217-07-4) → 3',4',5,5',6,7-Hexamethoxyflavone (29043-07-0)

Guidance literature:

With sodium acetate; acetic acid;

Reference yield:

6-hydroxy-2,3,4-trimethoxyacetophenone (22248-14-2) → 3',4',5,5',6,7-Hexamethoxyflavone (29043-07-0)

Guidance literature:

Multi-step reaction with 5 steps

1: CF₃COOH / benzene

2: KOH / pyridine

3: H₂SO₄ / acetic acid

4: H₂ / Pd-C / ethyl acetate

5: K₂CO₃ / acetone

With potassium hydroxide; sulfuric acid; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In pyridine; acetic acid; ethyl acetate; acetone; benzene;

upstream raw materials:

3',4',5',5,6,7-hexahydroxyflavone

dimethyl sulfate

1-(6-hydroxy-2,3,4-trimethoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propane-1,3-dione

diazomethane

Downstream raw materials:

5-hydroxyl-6,7,3′,4′,5′-pentamethoxyflavone

Eudesmic acid

Refernces

• 1、 Seringolam, Werner Herz,Govindan, V.,Riess-Maurer, Ingrid,Kreil, B.,Wagner, Hildebert,et al.. "ISOLATION AND SYNTHESIS OF TWO NEW FLAVONES FROM CONOCLINIUM COELESTINUM". . p. 669 - 672. Retrieved 1980.
• 2、 -. "Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs". Page/Page column 48; 49; 50; 52. . Retrieved 2017/07/01.
• 3、 Swaminathan, Meyyammai,Chee, Chin Fei,Chin, Sek Peng,Buckle, Michael J. C.,Rahman, Noorsaadah Abd.,Doughty, Stephen W.,Chung, Lip Yong. "Flavonoids with M1 muscarinic acetylcholine receptor binding activity". . p. 8933 - 8948. Retrieved 2014/08/05.