methyl 2-[(4-bromophenyl)amino]-2-oxoacetate

Base Information

• Chemical Name: methyl 2-[(4-bromophenyl)amino]-2-oxoacetate
• CAS No.: 480450-72-4
• Molecular Formula: C9H8BrNO3
• Molecular Weight: 258.071
• Mol file: 480450-72-4.mol

Synonyms:methyl N-(4-bromophenyl)oxamate;methyl 2-(4-bromoanilino)-2-oxoacetate;2-(4-bromoanilino)-2-oxoacetic acid methyl ester;N-(4-Bromo-phenyl)-oxalamic acid methyl ester;

Chemical Property of methyl 2-[(4-bromophenyl)amino]-2-oxoacetate

Chemical Property:

• Melting Point: 159 - 160 °C
• PSA: 55.40000
• LogP: 1.63360

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[(4-bromophenyl)amino]-2-oxoacetate

There total 4 articles about methyl 2-[(4-bromophenyl)amino]-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

dimethyl 2-((4-bromophenyl)amino)but-2-enedioate (107504-22-3) → methyl 2-[(4-bromophenyl)amino]-2-oxoacetate (480450-72-4)

Guidance literature:

With tert.-butylhydroperoxide; In water; chlorobenzene; at 80 ℃; for 2h;

DOI:10.1055/s-0036-1588990

Reference yield: 68.9%

→ methyl 2-[(4-bromophenyl)amino]-2-oxoacetate (480450-72-4)

Guidance literature:

Reference yield:

monomethyl oxalyl chloride (5781-53-3) + 4-bromo-aniline (106-40-1) → methyl 2-[(4-bromophenyl)amino]-2-oxoacetate (480450-72-4)

Guidance literature:

upstream raw materials:

methanol

monomethyl oxalyl chloride

4-bromo-aniline

dimethyl 2-((4-bromophenyl)amino)but-2-enedioate

Downstream raw materials:

1-(4-bromophenyl)indoline-2,3-dione

4-bromooxanilic acid

Refernces

• 1、 -. "PAI-1 INHIBITOR". Page/Page column 287. . Retrieved 2011/02/17.
• 2、 -. "N-Phenyloxamide derivatives". Page/Page column 49. . Retrieved 2008/12/08.