dodec-2-ynoic acid

Base Information

• Chemical Name: dodec-2-ynoic acid
• CAS No.: 67587-18-2
• Molecular Formula: C12H20O2
• Molecular Weight: 196.29
• Mol file: 67587-18-2.mol

Synonyms:

Chemical Property of dodec-2-ynoic acid

Chemical Property:

• Vapor Pressure: 6.78E-05mmHg at 25°C
• Boiling Point: 320.1°C at 760 mmHg
• Flash Point: 161.6°C
• Density: 0.959g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of dodec-2-ynoic acid

There total 5 articles about dodec-2-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-undecyne (2243-98-3) + carbon dioxide (124-38-9,18923-20-1) → 2-dodecynoic acid (67587-18-2)

Guidance literature:

1-undecyne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

carbon dioxide; In tetrahydrofuran; hexane; for 0.0833333h;

DOI:10.1002/ejoc.201900460

Reference yield:

dodec-2-ynoic acid ethyl ester (217963-31-0) → 2-dodecynoic acid (67587-18-2)

Guidance literature:

With lithium hydroxide; In methanol; for 12h; Ambient temperature;

DOI:10.7164/antibiotics.48.1467

Reference yield:

1-undecyne (2243-98-3) → 2-dodecynoic acid (67587-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi / hexane; tetrahydrofuran / 1 h / 0 °C

2: aq. LiOH / methanol / 12 h / Ambient temperature

With lithium hydroxide; n-butyllithium; In tetrahydrofuran; methanol; hexane;

DOI:10.7164/antibiotics.48.1467

upstream raw materials:

dodec-2-ynoic acid ethyl ester

carbon dioxide

methylammonium carbonate

1-undecyne

Downstream raw materials:

Dodec-2-ynoic acid 4-nitro-phenyl ester

2-methyldecanal

ethyl 3-oxododecanoate

1-undecyne

Refernces

• 1、 Sakai,Kawai,Kamishohara,Odagawa,Suzuki,Uchida,Kawasaki,Tsuruo,Otake. "Structure-antitumor activity relationship of semi-synthetic spicamycin derivatives". . p. 1467 - 1480. Retrieved 2007/10/03.