Dodec-2-ynoic acid 4-nitro-phenyl ester

Base Information

• Chemical Name: Dodec-2-ynoic acid 4-nitro-phenyl ester
• CAS No.: 1027162-52-2
• Molecular Formula: C₁₈H₂₃NO₄
• Molecular Weight: 317.385
• Mol file: 1027162-52-2.mol

Synonyms:

Chemical Property of Dodec-2-ynoic acid 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dodec-2-ynoic acid 4-nitro-phenyl ester

There total 3 articles about Dodec-2-ynoic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-undecyne (2243-98-3) → Dodec-2-ynoic acid 4-nitro-phenyl ester (1027162-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: n-BuLi / hexane; tetrahydrofuran / 1 h / 0 °C

2: aq. LiOH / methanol / 12 h / Ambient temperature

3: DCC / dimethylformamide / 12 h / Ambient temperature

With lithium hydroxide; n-butyllithium; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;

DOI:10.7164/antibiotics.48.1467

Reference yield:

dodec-2-ynoic acid ethyl ester (217963-31-0) → Dodec-2-ynoic acid 4-nitro-phenyl ester (1027162-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. LiOH / methanol / 12 h / Ambient temperature

2: DCC / dimethylformamide / 12 h / Ambient temperature

With lithium hydroxide; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

DOI:10.7164/antibiotics.48.1467

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 2-dodecynoic acid (67587-18-2) → Dodec-2-ynoic acid 4-nitro-phenyl ester (1027162-52-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 12h; Ambient temperature;

DOI:10.7164/antibiotics.48.1467

upstream raw materials:

4-nitro-phenol

2-dodecynoic acid

1-undecyne

dodec-2-ynoic acid ethyl ester

Refernces