2-Chloro-3-nitro-5-pyridinecarboxylic acid

Base Information

• Chemical Name: 2-Chloro-3-nitro-5-pyridinecarboxylic acid
• CAS No.: 7477-10-3
• Molecular Formula: C6H3ClN2O4
• Molecular Weight: 202.554
• Hs Code.: 2933399090
• Mol file: 7477-10-3.mol

Synonyms:Nicotinicacid, 6-chloro-5-nitro- (8CI);NSC 404695;

Chemical Property of 2-Chloro-3-nitro-5-pyridinecarboxylic acid

Chemical Property:

• Vapor Pressure: 3.67E-07mmHg at 25°C
• Refractive Index: 1.637
• Boiling Point: 401.3 °C at 760 mmHg
• PKA: 2.62±0.10(Predicted)
• Flash Point: 196.5 °C
• PSA: 96.01000
• Density: 1.702g/cm³
• LogP: 1.86460
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-5-nitronicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-nitro-5-pyridinecarboxylic acid

There total 5 articles about 2-Chloro-3-nitro-5-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-hydroxy-5-nitronicotinic acid (6635-31-0) → 6-chloro-5-nitronicotinic acid (7477-10-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; trichlorophosphate;

Reference yield: 85.0%

2-chloro-5-methyl-3-nitro-pyridine (23056-40-8) → 6-chloro-5-nitronicotinic acid (7477-10-3)

Guidance literature:

With sodium dichromate; sulfuric acid; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2015.01.016

Reference yield:

→ 6-chloro-5-nitronicotinic acid (7477-10-3)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; Behandeln des Reaktionsgemisches mit H₂O;

DOI:10.1021/ja01583a047

upstream raw materials:

6-hydroxy-5-nitronicotinic acid

(5-methyl-pyridin-2-yl)amine

2-hydroxy-5-methyl-3-nitropyridine

2-chloro-5-methyl-3-nitro-pyridine

Downstream raw materials:

8-nitro-tetrazolopyridin-6-carboxylic acid

6-chloro-5-nitropyridin-3-ylmethanol

5-amino-6-chloropyridin-3-ylmethanol

5-azido-6-chloropyridin-3-ylmethyl chloride