3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

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Chemical Name:3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride
CAS No.:714218-76-5
Molecular Formula:C₁₉H₂₆N₆O₄S*ClH
Molecular Weight:470.98
Hs Code.:

Synonyms:3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

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Chemical Property of 3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

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Technology Process of 3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

There total 5 articles about 3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 486422-11-1
4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid

: 714218-67-4
3-amino-6-bromo-N-(2-methoxyethyl)pyrazine-2-carboxamide

: 714218-76-5
3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

Guidance literature:: 4-[(4-methylpiperazin-1-yl)sulfonyl]phenylboronic acid; 3-amino-6-bromo-N-(2-methoxyethyl)pyrazine-2-carboxamide; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In tetrahydrofuran; water; at 70 ℃; Microwave irradiation;

With hydrogenchloride; In diethyl ether;
DOI:10.1021/jm201724m

Reference yield: 44.0%

: 714218-76-5
3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

Guidance literature:

Reference yield:

: 486424-37-7
3-amino-6-bromo-pyrazine-2-carboxylic acid

: 714218-76-5
3-amino-N-(2-methoxyethyl)-6-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}pyrazine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-1H-benzotriazol hydrate / acetonitrile / 0.25 h

1.2: 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / tetrahydrofuran; water / 70 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1-hydroxy-1H-benzotriazol hydrate; sodium carbonate; In tetrahydrofuran; water; acetonitrile; 2.1: |Suzuki Coupling;
DOI:10.1021/jm201724m