3,5,21-Trioxa-4,22-disilatetracos-8-en-16-one, 14,18-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,2,7,9,13,15,17,17,22,2 2,23,23-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]- 4,4-diphenyl-, (6S,7S,8Z,13S,14S,15R,18S)-

Base Information

Chemical Name:3,5,21-Trioxa-4,22-disilatetracos-8-en-16-one, 14,18-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,2,7,9,13,15,17,17,22,2 2,23,23-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]- 4,4-diphenyl-, (6S,7S,8Z,13S,14S,15R,18S)-
CAS No.:488791-47-5
Molecular Formula:C62H107NO6SSi4
Molecular Weight:1106.94
Hs Code.:
Mol file:488791-47-5.mol

3,5,21-Trioxa-4,22-disilatetracos-8-en-16-one,
14,18-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,2,7,9,13,15,17,17,22,2
2,23,23-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-
4,4-diphenyl-, (6S,7S,8Z,13S,14S,15R,18S)-

Synonyms:

Suppliers and Price of 3,5,21-Trioxa-4,22-disilatetracos-8-en-16-one, 14,18-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,2,7,9,13,15,17,17,22,2 2,23,23-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]- 4,4-diphenyl-, (6S,7S,8Z,13S,14S,15R,18S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5,21-Trioxa-4,22-disilatetracos-8-en-16-one, 14,18-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,2,7,9,13,15,17,17,22,2 2,23,23-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]- 4,4-diphenyl-, (6S,7S,8Z,13S,14S,15R,18S)-

Chemical Property:

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Technology Process of 3,5,21-Trioxa-4,22-disilatetracos-8-en-16-one, 14,18-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,2,7,9,13,15,17,17,22,2 2,23,23-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]- 4,4-diphenyl-, (6S,7S,8Z,13S,14S,15R,18S)-

There total 14 articles about 3,5,21-Trioxa-4,22-disilatetracos-8-en-16-one, 14,18-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,2,7,9,13,15,17,17,22,2 2,23,23-dodecamethyl-6-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]- 4,4-diphenyl-, (6S,7S,8Z,13S,14S,15R,18S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (12Z,16E)-(3S,6R,8S,14S,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one

: 488791-47-5
(12Z,16E)-(3S,6R,7S,8S,14S,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ja028196l

Reference yield: 94.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 488791-45-3
(12Z,16E)-(3S,6R,7S,8S,14S,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3-bis-(tert-butyl-dimethyl-silanyloxy)-7-hydroxy-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one

: 488791-47-5
(12Z,16E)-(3S,6R,7S,8S,14S,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one

Guidance literature:: DOI:10.1039/b312213c

Reference yield:

: 488791-41-9
(6Z,10E)-(2S,8S,9S)-9-(tert-Butoxy-diphenyl-silanyloxy)-2,6,8,10-tetramethyl-11-(2-methyl-thiazol-4-yl)-undeca-6,10-dien-1-ol

: 488791-47-5
(12Z,16E)-(3S,6R,7S,8S,14S,15S)-15-(tert-Butoxy-diphenyl-silanyloxy)-1,3,7-tris-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,12,14,16-heptamethyl-17-(2-methyl-thiazol-4-yl)-heptadeca-12,16-dien-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / PCC

2: 69 percent / LDA

With pyridinium chlorochromate; lithium diisopropyl amide;
DOI:10.1039/b312213c