(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one

Base Information

Chemical Name:(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
CAS No.:187527-25-9
Molecular Formula:C21H46O3Si2
Molecular Weight:402.765
Hs Code.:
DSSTox Substance ID:DTXSID10432712
Nikkaji Number:J820.576K
Wikidata:Q82246819
Mol file:187527-25-9.mol

Synonyms:187527-25-9;(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one;(5S)-5,7-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4-dimethylheptan-3-one;(5S)-5,7-BIS-[(TERT-BUTYLDIMETHYLSILYL)OXY]-4,4-DIMETHYLHEPTAN-3-ONE;SCHEMBL2070144;DTXSID10432712;AKOS030241660;J-012071;(5S)-4,4-Dimethyl-5,7-di(tert-butyldimethylsiloxy)-3-heptanone;(5s)-5,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-heptan-3-one

Suppliers and Price of (5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
2g
$ 1100.00

TRC
(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
250mg
$ 165.00

Medical Isotopes, Inc.
(5S)-5,7-Bis-[[tert-butyldimethylsilyl)oxy]]-4,4-dimethylheptan-3-one
1.25 g
$ 1720.00

Biosynth Carbosynth
(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
2 g
$ 1310.40

Biosynth Carbosynth
(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
100 mg
$ 122.00

Biosynth Carbosynth
(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
250 mg
$ 222.50

Biosynth Carbosynth
(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
1 g
$ 720.80

Biosynth Carbosynth
(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
500 mg
$ 400.00

American Custom Chemicals Corporation
(5S)-5,7-BIS-[[(TERT-BUTYLDIMETHYLSILYL)OXY]]-4,4-DIMETHYLHEPTAN-3-ONE 95.00%
250MG
$ 329.70

AK Scientific
(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one
100mg
$ 214.00

Total 3 raw suppliers

Chemical Property of (5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:409.566oC at 760 mmHg
Flash Point:167.42oC
PSA：35.53000
LogP:6.79400
Solubility.:Dichloromethane, Ether, Ethyl Acetate, Hexane
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:11
Exact Mass:402.29854839
Heavy Atom Count:26
Complexity:469

Purity/Quality:

98%Min ^*data from raw suppliers

(5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)C(C)(C)C(CCO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
Isomeric SMILES:CCC(=O)C(C)(C)[C@H](CCO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C

Technology Process of (5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one

There total 51 articles about (5S)-5,7-Bis-{[tert-butyldimethylsilyl)oxy]}-4,4-dimethylheptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 255398-79-9
(-)-(5S)-5,7-bis(tert-butyldimethylsilyloxy)-4,4-dimethylheptan-3-ol

: 187527-25-9
(-)-(5S)-5,7-bis{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylheptan-3-one

Guidance literature:: With pyridine; Dess-Martin periodane; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jo0007480

Reference yield: 94.0%

: 218614-14-3
(4S)-4,6-bis{[tert-butyl(dimethyl)silyl]oxy}-3,3-dimethylhexan-2-one

: 74-88-4
methyl iodide

: 187527-25-9
(-)-(5S)-5,7-bis{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylheptan-3-one

Guidance literature:: (4S)-4,6-bis{[tert-butyl(dimethyl)silyl]oxy}-3,3-dimethylhexan-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -15 ℃; for 2h;

methyl iodide; In tetrahydrofuran; at -78 - -40 ℃;
DOI:10.1002/anie.200351413

Reference yield: 90.0%

: 599-70-2
ethyl phenyl sulfone

: 218614-13-2
(-)-methyl (3S)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpentanoate

: 187527-25-9
(-)-(5S)-5,7-bis{[tert-butyl(dimethyl)silyl]oxy}-4,4-dimethylheptan-3-one

Guidance literature:: ethyl phenyl sulfone; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.5h;

(-)-methyl (3S)-3,5-bis{[tert-butyl(dimethyl)silyl]oxy}-2,2-dimethylpentanoate; In tetrahydrofuran; at -78 - 20 ℃; Further stages;
DOI:10.1021/jo901752v