Technology Process of 2,7,9,14-Tetraazapentadecanedioic acid,
8-oxo-2,14-bis(phenylmethoxy)-, 1,1-dimethylethyl 2,2,2-trichloroethyl
ester
There total 6 articles about 2,7,9,14-Tetraazapentadecanedioic acid,
8-oxo-2,14-bis(phenylmethoxy)-, 1,1-dimethylethyl 2,2,2-trichloroethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 80 percent / NaH; NaI / dimethylformamide / 5 h / 60 - 70 °C
2.1: ammonium hydroxide; ammonia / Raney 2800 nickel / methanol; H2O / 0.33 h / 0 - 5 °C
2.2: H2 / Raney nickel / methanol / 5 h / 2327.23 Torr
3.1: 2.5360 g / toluene / 8 h
With
ammonium hydroxide; ammonia; sodium hydride; sodium iodide;
Raney 2800 nickel;
In
methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo026391c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ammonium hydroxide; ammonia / Raney 2800 nickel / methanol; H2O / 0.33 h / 0 - 5 °C
1.2: H2 / Raney nickel / methanol / 5 h / 2327.23 Torr
2.1: 2.5360 g / toluene / 8 h
With
ammonium hydroxide; ammonia;
Raney 2800 nickel;
In
methanol; water; toluene;
DOI:10.1021/jo026391c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3.37 g / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 8 h
2: 90 percent / hydrochloric acid / dioxane; H2O / 16 h / Heating
3: diphenylphosphoryl azide; triethylamine / toluene / 6 h
4: 2.5360 g / toluene / 8 h
With
hydrogenchloride; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; water; toluene;
3: Curtius rearrangement;
DOI:10.1021/jo026391c
