2,5-DIMETHOXY-4-METHYLBENZALDEHYDE

Base Information

• Chemical Name: 2,5-DIMETHOXY-4-METHYLBENZALDEHYDE
• CAS No.: 4925-88-6
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2912499000
• Mol file: 4925-88-6.mol

Synonyms:2,5-Dimethoxy-4-methyl-benzaldehyde;

Chemical Property of 2,5-DIMETHOXY-4-METHYLBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000723mmHg at 25°C
• Melting Point: 82-86℃
• Boiling Point: 307.5oC at 760 mmHg
• Flash Point: 130.7oC
• PSA: 35.53000
• Density: 1.089g/cm3
• LogP: 1.82470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Soluble in dichloromethane, dimethyl sulfoxide and methanol. Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dimethoxy-4-methyl-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,5-Dimethoxy-4-methylbenzaldehyde is used in the preparation of phenylamine derivative as potential psychotomimetics.

Technology Process of 2,5-DIMETHOXY-4-METHYLBENZALDEHYDE

There total 10 articles about 2,5-DIMETHOXY-4-METHYLBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,5-dimethoxy toluene (24599-58-4) + N-methyl-N-phenylformamide (93-61-8) → 2,5-dimethoxy-4-methylbenzaldehyde (4925-88-6)

Guidance literature:

N-methyl-N-phenylformamide; With trichlorophosphate; at 20 ℃; for 0.833333h; Inert atmosphere;

2,5-dimethoxy toluene; at 70 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo3016055

Reference yield: 85.9%

2,5-dimethoxy toluene (24599-58-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,5-dimethoxy-4-methylbenzaldehyde (4925-88-6)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 8h;

Reference yield: 80.0%

2,5-dihydroxy-4-methylbenzaldehyde (52010-89-6) + methyl iodide (74-88-4) → 2,5-dimethoxy-4-methylbenzaldehyde (4925-88-6)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 18h;

DOI:10.1055/a-0810-7033

upstream raw materials:

Dichloromethyl methyl ether

2,5-dimethoxy toluene

dicyanozinc

2,5-dimethoxy-4-methylphenylmethanol

Downstream raw materials:

2,5-Dimethoxy-4-methyl-β-nitrostyrol

1-(2,5-Dimethoxy-4-methyl-phenyl)-2-nitro-propen

1-(2,5-Dimethoxy-4-methyl-phenyl)-2-nitro-1-propan

2,5-dimethoxy-4-methyl-benzonitrile

Refernces

• 1、 Kumar, P. Ravi,Yennam, Satyanarayana,Raghavulu,Velatooru, Loka Reddy,Kotla, Siva Reddy,Penugurti, Vasudevarao,Hota, Prasanta K.,Behera, Manoranjan,Jaya Shree. "Synthesis of Novel Diaziridinyl Quinone Isoxazole Hybrids and Evaluation of Their Anti-Cancer Activity as Potential Tubulin-Targeting Agents". . p. 406 - 414. Retrieved 2019/07/10.
• 2、 Miyawaki, Akari,Kikuchi, Daisuke,Niki, Masu,Manabe, Yuki,Kanematsu, Makoto,Yokoe, Hiromasa,Yoshida, Masahiro,Shishido, Kozo. "Total synthesis of natural enantiomers of heliespirones A and C via the diastereoselective intramolecular Hosomi-Sakurai reaction". . p. 8231 - 8243. Retrieved 2013/01/15.