Larreantin

Base Information

Chemical Name:Larreantin
CAS No.:114094-46-1
Molecular Formula:C₂₇H₂₄O₇
Molecular Weight:460.483
Hs Code.:
UNII:67XK94LC26
Nikkaji Number:J437.254I
Wikidata:Q105215468

Synonyms:Larreantin;67XK94LC26;UNII-67XK94LC26;1,4-Naphthalenedione, 8-(4-hydroxy-3-methoxyphenyl)-6-((4-hydroxy-3-methoxyphenyl)methyl)-2-methoxy-7-methyl-;114094-46-1;8-(4-Hydroxy-3-methoxyphenyl)-6-((4-hydroxy-3-methoxyphenyl)methyl)-2-methoxy-7-methyl-1,4-naphthalenedione

Suppliers and Price of Larreantin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Larreantin

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:460.15220310
Heavy Atom Count:34
Complexity:779

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C2=C(C=C1CC3=CC(=C(C=C3)O)OC)C(=O)C=C(C2=O)OC)C4=CC(=C(C=C4)O)OC

Technology Process of Larreantin

There total 21 articles about Larreantin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88275-87-0
3-bromo-2-methyloxybenzaldehyde

: 114094-46-1
larreantin

Guidance literature:: Multi-step reaction with 21 steps

1: 91 percent / benzene / 20 h / Heating

2: 95 percent / 90percent aq. CF₃COOH / 0.25 h / 25 °C

3: 84 percent / AcOK / 0.08 h / Heating

4: 94 percent / diisobutylaluminium hydride / tetrahydrofuran / -10 °C

5: 82 percent / K₂CO₃ / dimethylformamide / 96 h / 25 °C

6: 90 percent / MnO₂ / CH₂Cl₂ / 12 h / 25 °C

7: p-ClC₆H₄CO₃H / CH₂Cl₂ / 72 h / Heating

8: NaOMe, MeOH / 0.08 h

9: K₂CO₃ / dimethylformamide / 72 h / 50 °C

10: 95 percent / dimethylformamide / 12 h / Heating

11: 85 percent / NaOH / methanol; H₂O / 96 h / Heating

12: (COCl)2 / CH₂Cl₂ / 2.5 h / 25 °C

13: CH₂Cl₂ / 2 h / 25 °C

14: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

15: 88 percent / tetrahydrofuran / 0.75 h / 25 °C

16: 1.) BuLi, TMEDA / 1.) THF, -78 deg C, 1 h

17: HCl / dioxane / 0.5 h / Heating

18: 99 percent / LiAlH₄ / tetrahydrofuran / 2 h / 25 °C

19: 80 percent / H₂, Et₃N, (CF₃CO)2O / Pd/C / tetrahydrofuran / 18 h

20: 1.) BCl₃, 2.) KOH, air / 1.) CH₂Cl₂, -10 deg C, 8 h, 2.) EtOH/EtOAc, 30 s

21: KHCO₃ / dimethylformamide / 8 h

With hydrogenchloride; methanol; manganese(IV) oxide; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; oxalyl dichloride; air; N,N,N,N,-tetramethylethylenediamine; p-chloroperbenzoic acid; hydrogen; sodium methylate; potassium acetate; boron trichloride; diisobutylaluminium hydride; potassium carbonate; potassium hydrogencarbonate; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39910000190

Reference yield:

: 133593-69-8
6-Bromo-3-(hydroxymethyl)-5-methoxy-1-naphthol

: 114094-46-1
larreantin

Guidance literature:: Multi-step reaction with 17 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 96 h / 25 °C

2: 90 percent / MnO₂ / CH₂Cl₂ / 12 h / 25 °C

3: p-ClC₆H₄CO₃H / CH₂Cl₂ / 72 h / Heating

4: NaOMe, MeOH / 0.08 h

5: K₂CO₃ / dimethylformamide / 72 h / 50 °C

6: 95 percent / dimethylformamide / 12 h / Heating

7: 85 percent / NaOH / methanol; H₂O / 96 h / Heating

8: (COCl)2 / CH₂Cl₂ / 2.5 h / 25 °C

9: CH₂Cl₂ / 2 h / 25 °C

10: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

11: 88 percent / tetrahydrofuran / 0.75 h / 25 °C

12: 1.) BuLi, TMEDA / 1.) THF, -78 deg C, 1 h

13: HCl / dioxane / 0.5 h / Heating

14: 99 percent / LiAlH₄ / tetrahydrofuran / 2 h / 25 °C

15: 80 percent / H₂, Et₃N, (CF₃CO)2O / Pd/C / tetrahydrofuran / 18 h

16: 1.) BCl₃, 2.) KOH, air / 1.) CH₂Cl₂, -10 deg C, 8 h, 2.) EtOH/EtOAc, 30 s

17: KHCO₃ / dimethylformamide / 8 h

With hydrogenchloride; methanol; manganese(IV) oxide; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; oxalyl dichloride; air; N,N,N,N,-tetramethylethylenediamine; p-chloroperbenzoic acid; hydrogen; sodium methylate; boron trichloride; potassium carbonate; potassium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c39910000190

Reference yield:

: 7-Bromo-4-isopropoxy-8-methoxy-naphthalen-2-ol

: 114094-46-1
larreantin

Guidance literature:: Multi-step reaction with 13 steps

1: K₂CO₃ / dimethylformamide / 72 h / 50 °C

2: 95 percent / dimethylformamide / 12 h / Heating

3: 85 percent / NaOH / methanol; H₂O / 96 h / Heating

4: (COCl)2 / CH₂Cl₂ / 2.5 h / 25 °C

5: CH₂Cl₂ / 2 h / 25 °C

6: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

7: 88 percent / tetrahydrofuran / 0.75 h / 25 °C

8: 1.) BuLi, TMEDA / 1.) THF, -78 deg C, 1 h

9: HCl / dioxane / 0.5 h / Heating

10: 99 percent / LiAlH₄ / tetrahydrofuran / 2 h / 25 °C

11: 80 percent / H₂, Et₃N, (CF₃CO)2O / Pd/C / tetrahydrofuran / 18 h

12: 1.) BCl₃, 2.) KOH, air / 1.) CH₂Cl₂, -10 deg C, 8 h, 2.) EtOH/EtOAc, 30 s

13: KHCO₃ / dimethylformamide / 8 h

With hydrogenchloride; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; oxalyl dichloride; air; N,N,N,N,-tetramethylethylenediamine; hydrogen; boron trichloride; potassium carbonate; potassium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c39910000190