2-(Hydroxymethyl)-2-(2-hydroxybenzylideneamino)-1,3-propanediol

Base Information

• Chemical Name: 2-(Hydroxymethyl)-2-(2-hydroxybenzylideneamino)-1,3-propanediol
• CAS No.: 18212-81-2
• Molecular Formula: C11H15NO4
• Molecular Weight: 225.244
• Hs Code.: 2925290090
• DSSTox Substance ID: DTXSID20425352
• Nikkaji Number: J227.641K,J2.974.809H
• Mol file: 18212-81-2.mol

Synonyms:18212-81-2;2-(Hydroxymethyl)-2-(2-hydroxybenzylideneamino)-1,3-propanediol;2-(hydroxymethyl)-2-[(2-hydroxyphenyl)methylideneamino]propane-1,3-diol;AC1O9KTP;Salicylaldehyde trisbuffer;Oprea1_132654;DTXSID20425352;AKOS024331923;tris(hydroxymethyl)(salicylideneamino)methane;2-[(2-hydroxybenzylidene)amino]-2-(hydroxymethyl)-1,3-propanediol;2-[(E)-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]iminomethyl]phenol;2-{[tris(hydroxymethyl)methyl]aminomethylene}cyclohexa-3,5-dien-1(2H)-one;6-[(2-hydroxy-1,1-bis-hydroxymethyl-ethylamino)-methylen]-cyclohexa-2,4-dienone

Chemical Property of 2-(Hydroxymethyl)-2-(2-hydroxybenzylideneamino)-1,3-propanediol

Chemical Property:

• PSA: 89.79000
• LogP: -0.73840
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 225.10010796
• Heavy Atom Count: 16
• Complexity: 220

Purity/Quality:

99% ^*data from raw suppliers

2-((2-HYDROXY-BENZYLIDENE)-AMINO)-2-HYDROXYMETHYL-PROPANE-1,3-DIOL Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=NC(CO)(CO)CO)O

Technology Process of 2-(Hydroxymethyl)-2-(2-hydroxybenzylideneamino)-1,3-propanediol

There total 4 articles about 2-(Hydroxymethyl)-2-(2-hydroxybenzylideneamino)-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%

salicylaldehyde (90-02-8) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → 2-((2-hydroxy-benzylidene)-amino)-2-hydroxymethyl-propane-1,3-diol (18212-81-2)

Guidance literature:

In methanol; at 45 ℃; for 1h;

DOI:10.1016/j.poly.2013.03.055

Reference yield: 88.0%

2,2,2-tris(hydroxymethyl)ethylamine (7332-39-0) + salicylaldehyde (90-02-8) → 2-((2-hydroxy-benzylidene)-amino)-2-hydroxymethyl-propane-1,3-diol (18212-81-2)

Guidance literature:

In ethanol; at 100 ℃; for 3h;

DOI:10.1016/j.poly.2016.02.042

Reference yield:

2-methyl-benzyl alcohol (89-95-2) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → 2-((2-hydroxy-benzylidene)-amino)-2-hydroxymethyl-propane-1,3-diol (18212-81-2)

Guidance literature:

In methanol; at 40 ℃; for 1h;

DOI:10.1002/1099-0682(200208)2002:8<2207::AID-EJIC2207>3.0.CO;2-N

upstream raw materials:

salicylaldehyde

2-amino-2-hydroxymethyl-1,3-propanediol

2-methyl-benzyl alcohol

2,2,2-tris(hydroxymethyl)ethylamine

Refernces

• 1、 Lazarou, Katerina N.,Savvidou, Aikaterini,Raptopoulou, Catherine P.,Psycharis, Vassilis. "3D supramolecular networks based on hydroxyl-rich Schiff-base copper(II) complexes". . p. 125 - 137. Retrieved 2018.
• 2、 Dey, Mishtu,Pulla Rao, Chebrolu,Saarenketo, Pauli,Rissanen, Kari,Kolehmainen, Erkki. "Four-, five- and six-coordinated ZnII complexes of OH-containing ligands: Syntheses, structure and reactivity". . p. 2207 - 2215. Retrieved 2002.
• 3、 Cintas, Pedro,Martínez, R. Fernando,Matamoros, Esther,Palacios, Juan C.. "Imine or Enamine? Insights and Predictive Guidelines from the Electronic Effect of Substituents in H-Bonded Salicylimines". supporting information. p. 5838 - 5862. Retrieved 2020/05/20.
• 4、 -. "ONO-type Schiff base palladium (II) complex containing multiple coordination sites and preparation method and application thereof". Paragraph 00035-0039. . Retrieved 2018/10/19.