2-Quinolinecarboxylic acid, 7-bromo-8-(phenylmethoxy)-

Base Information

Chemical Name:2-Quinolinecarboxylic acid, 7-bromo-8-(phenylmethoxy)-
CAS No.:495409-83-1
Molecular Formula:C17H12BrNO3
Molecular Weight:358.191
Hs Code.:

Synonyms:

Suppliers and Price of 2-Quinolinecarboxylic acid, 7-bromo-8-(phenylmethoxy)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Quinolinecarboxylic acid, 7-bromo-8-(phenylmethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Quinolinecarboxylic acid, 7-bromo-8-(phenylmethoxy)-

There total 1 articles about 2-Quinolinecarboxylic acid, 7-bromo-8-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 99573-20-3
2-Amino-3-(benzyloxy)-4-bromobenzaldehyde

: 127-17-3
2-oxo-propionic acid

: 495409-83-1
8-benzyloxy-7-bromo-quinoline-2-carboxylic acid

Guidance literature:: 2-Amino-3-(benzyloxy)-4-bromobenzaldehyde; 2-oxo-propionic acid; With sodium hydroxide; In methanol; at 60 ℃;

With hydrogenchloride; water; pH=2;

Reference yield:

: 495409-83-1
8-benzyloxy-7-bromo-quinoline-2-carboxylic acid

: streptonigrone

Guidance literature:: Multi-step reaction with 16 steps

1: HCl / 5 h / 24 °C

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min

3: 81 percent / piperidine / ethanol / 1 h / Heating

4: 75 percent / TiCl₄, Et₃N / CH₂Cl₂ / 6.5 h / 0 - 25 °C

5: t-BuOK / benzene / 3 h / 24 °C

6: DDQ / tetrahydrofuran / 1 h / -30 °C

7: 92 percent / Na₂CO₃ / tetrahydrofuran / 4 h / 25 °C

8: 81 percent / i-Pr₂NEt / CHCl₃ / 6 h / Heating

9: 42 percent / 4 N aq. LiOH / dimethylsulfoxide / 26 h / 130 - 135 °C

10: 1.) Et₃N, diphenyl phosphorazidate, 2.) 4 N aq. LiOH / 1.) benzene, a) 25 deg C, 15 min, b) reflux, 7 h, 2.) 25 deg C, 1 h

11: 80 percent / HgBr(g) / CH₂Cl₂ / 2 h / 0 °C

12: 69 percent / aq. potassium nitrosulfonate, Bu₄NHSO₄ / CH₂Cl₂ / 4 h / 25 °C

13: 1.) Ti(O-i-Pr)4, 2.) NaOMe / 1.) THF, 0 deg C, 45 min, 2.) THF, 0 deg C, 1 h

14: 85 percent / aq. NaN₃ / 21 h / 25 °C

15: 86 percent / NaBH₄ / tetrahydrofuran; methanol / 1 h / 25 °C

16: TFA, H₂, HBr / 10percent Pd/C / 1 h / 80 °C

With piperidine; titanium(IV) isopropylate; hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; sodium azide; potassium nitrosulfonate; diphenyl phosphoryl azide; potassium tert-butylate; hydrogen bromide; hydrogen; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; mercury(I) bromide; titanium tetrachloride; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; benzene;
DOI:10.1021/ja00076a035

Reference yield:

: 495409-83-1
8-benzyloxy-7-bromo-quinoline-2-carboxylic acid

: 152455-84-0
3-amino-2-(7'-bromo-8'-hydroxyquinolin-2'-yl)-4-(3',4'-dimethoxy-2'-hydroxyphenyl)-6-methoxy-5-methylpyridine

Guidance literature:: Multi-step reaction with 11 steps

1: HCl / 5 h / 24 °C

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min

3: 81 percent / piperidine / ethanol / 1 h / Heating

4: 75 percent / TiCl₄, Et₃N / CH₂Cl₂ / 6.5 h / 0 - 25 °C

5: t-BuOK / benzene / 3 h / 24 °C

6: DDQ / tetrahydrofuran / 1 h / -30 °C

7: 92 percent / Na₂CO₃ / tetrahydrofuran / 4 h / 25 °C

8: 81 percent / i-Pr₂NEt / CHCl₃ / 6 h / Heating

9: 42 percent / 4 N aq. LiOH / dimethylsulfoxide / 26 h / 130 - 135 °C

10: 1.) Et₃N, diphenyl phosphorazidate, 2.) 4 N aq. LiOH / 1.) benzene, a) 25 deg C, 15 min, b) reflux, 7 h, 2.) 25 deg C, 1 h

11: 80 percent / HgBr(g) / CH₂Cl₂ / 2 h / 0 °C

With piperidine; hydrogenchloride; lithium hydroxide; diphenyl phosphoryl azide; potassium tert-butylate; mercury(I) bromide; titanium tetrachloride; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; benzene;
DOI:10.1021/ja00076a035