N-Boc-4-cyanopiperidine-4-carboxylic acid/1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid

Base Information

• Chemical Name: N-Boc-4-cyanopiperidine-4-carboxylic acid/1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid
• CAS No.: 495415-34-4
• Molecular Formula: C12H18N2O4
• Molecular Weight: 254.286
• Hs Code.: 2933399090
• Mol file: 495415-34-4.mol

Synonyms:N-BOC-4-CYANOPIPERIDINE-4-CARBOXYLIC ACID;1-tert-butoxycarbonyl-4-cyano-4-piperidinecarboxylic acid;4-cyano-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester;

Chemical Property of N-Boc-4-cyanopiperidine-4-carboxylic acid/1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid

Chemical Property:

• PSA: 90.63000
• LogP: 1.54978
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-4-cyanopiperidine-4-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-4-cyanopiperidine-4-carboxylic acid/1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid

There total 3 articles about N-Boc-4-cyanopiperidine-4-carboxylic acid/1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (1016258-66-4) → 1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid (495415-34-4)

Guidance literature:

1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate; With lithium hydroxide; In tetrahydrofuran; at 25 ℃; for 18h;

With water; citric acid;

Reference yield: 97.0%

→ 1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid (495415-34-4)

Guidance literature:

Reference yield:

1-tert-butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate (362703-34-2) → 1-(tert-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid (495415-34-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate

1-tert-butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate

Downstream raw materials:

4-cyano-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid (4-chloro-phenyl)amide

4-cyano-piperidine-4-carboxylic acid (4-chloro-phenyl)amide

(R)-tert-butyl 4-(1-(4-chlorophenyl)ethylcarbamoyl)-4-cyanopiperidine-1-carboxylate

tert-butyl 4-((1H-indol-2-yl)methylcarbamoyl)-4-cyanopiperidine-1-carboxylate