2-Chloro-7-methoxyquinoline

Base Information

• Chemical Name: 2-Chloro-7-methoxyquinoline
• CAS No.: 49609-15-6
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.633
• Hs Code.: 2933499090
• European Community (EC) Number: 822-346-9
• DSSTox Substance ID: DTXSID50497229
• Wikidata: Q82346653
• Mol file: 49609-15-6.mol

Synonyms:2-Chloro-7-methoxyquinoline;49609-15-6;2-chloro-7-methoxy-quinoline;MFCD13192242;Quinoline, 2-chloro-7-methoxy-;SCHEMBL622376;DTXSID50497229;FOARXBSDMBUBEG-UHFFFAOYSA-N;ZBA60915;AKOS016002062;SB68290;DS-15782;SY108816;CS-0135015;EN300-207869;P16665

Chemical Property of 2-Chloro-7-methoxyquinoline

Chemical Property:

• Melting Point: 97-98 °C
• Boiling Point: 145 °C(Press: 0.6 Torr)
• PKA: 0.65±0.50(Predicted)
• PSA: 22.12000
• Density: 1.267±0.06 g/cm3(Predicted)
• LogP: 2.89680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 193.0294416
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-7-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C=CC(=N2)Cl

Technology Process of 2-Chloro-7-methoxyquinoline

There total 10 articles about 2-Chloro-7-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-methoxyquinolin-2(1H)-one (23981-26-2) → 2-chloro-7-methoxyquinoline (49609-15-6)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

Reference yield: 96.0%

2-chloroquinoline-7-ol (375358-19-3) + methyl iodide (74-88-4) → 2-chloro-7-methoxyquinoline (49609-15-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 12h;

Reference yield:

(E)-N-(3-methoxyphenyl)-3-ethoxypropenamide → 2-chloro-7-methoxyquinoline (49609-15-6) + 2-chloro-5-methoxyquinoline (160893-07-2)

Guidance literature:

(E)-N-(3-methoxyphenyl)-3-ethoxypropenamide; With hydrogenchloride;

With trichlorophosphate; Further stages.;

DOI:10.1021/jm0200097

upstream raw materials:

m-Anisidine

N-(3-methoxyphenyl)cinnamamide

7-methoxyquinolin-2(1H)-one

(E)-ethyl 3-(4-methoxy-2-nitrophenyl)acrylate

Downstream raw materials:

2-chloroquinoline-7-ol

C₂₅H₃₂N₄O₂

C₂₄H₃₀N₄O₂

C₂₃H₂₈N₄O₂