3-Formyl-5-methoxychromone

Base Information

Chemical Name:3-Formyl-5-methoxychromone
CAS No.:49619-59-2
Molecular Formula:C11H8O4
Molecular Weight:204.182
Hs Code.:
DSSTox Substance ID:DTXSID301235976
Metabolomics Workbench ID:73942
Nikkaji Number:J1.048.341G
Mol file:49619-59-2.mol

Synonyms:3-FORMYL-5-METHOXYCHROMONE;49619-59-2;5-methoxy-4-oxo-4H-chromene-3-carbaldehyde;4H-1-Benzopyran-3-carboxaldehyde, 5-methoxy-4-oxo-;SCHEMBL1573192;5-methoxychromone-3-carboxaldehyde;DTXSID301235976;3-Formyl-5-methoxychromone, AldrichCPR;5-Methoxy-4-oxo-4H-1-benzopyran-3-carboxaldehyde

Suppliers and Price of 3-Formyl-5-methoxychromone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-Formyl-5-methoxychromone

Chemical Property:

Boiling Point:366.8±42.0 °C(Predicted)
PSA：0.00000
Density:1.401±0.06 g/cm3(Predicted)
LogP:0.00000
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:204.04225873
Heavy Atom Count:15
Complexity:308

Purity/Quality:: 97-99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC2=C1C(=O)C(=CO2)C=O

Technology Process of 3-Formyl-5-methoxychromone

There total 4 articles about 3-Formyl-5-methoxychromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 79-37-8
oxalyl dichloride

: 703-23-1
2'-hydroxy-6'-methoxyacetophenone

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 49619-59-2
5-methoxyl-4-oxo-<1>benzopyran-3-carboxaldehyde

Guidance literature:: 2'-hydroxy-6'-methoxyacetophenone; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

oxalyl dichloride; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.2174/1573406412666160314151900

Reference yield: 77.0%

: 703-23-1
2'-hydroxy-6'-methoxyacetophenone

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 49619-59-2
5-methoxyl-4-oxo-<1>benzopyran-3-carboxaldehyde

Guidance literature:: With trichlorophosphate; at 60 ℃;
DOI:10.1016/S0040-4020(01)01131-0

Reference yield:

: 699-83-2
2,6-dihydroxylacetophenone

: 49619-59-2
5-methoxyl-4-oxo-<1>benzopyran-3-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 8 h / Reflux

2.1: trichlorophosphate / 2 h / 20 - 50 °C

2.2: 50 °C

With potassium carbonate; trichlorophosphate; In acetone;
DOI:10.1002/chem.201003572