N-(1-(naphthalen-1-yl)ethyl)forMaMide

Base Information

• Chemical Name: N-(1-(naphthalen-1-yl)ethyl)forMaMide
• CAS No.: 49681-33-6
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol file: 49681-33-6.mol

Synonyms:Formamide, N-[1-(1-naphthalenyl)ethyl]-, (±)-;Formamide, N-[1-(1-naphthalenyl)ethyl]-;

Chemical Property of N-(1-(naphthalen-1-yl)ethyl)forMaMide

Chemical Property:

• Boiling Point: 420.7±24.0 °C(Predicted)
• PKA: 15.43±0.23(Predicted)
• PSA: 29.10000
• Density: 1.108±0.06 g/cm3(Predicted)
• LogP: 3.67360

Purity/Quality:

≥95% ^*data from raw suppliers

N-[1-(1-Naphthalenyl)ethyl]formamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-[1-(1-Naphthalenyl)ethyl]formamide is derived from 1-Acetylnaphthalene (A186940), which is used in the preparation of S(-)-1-(1''-naphthyl) ethanol, an important synthetic intermediate of mevinic acid analog;Also, it is used in the preparation of (R)-(+)-1-(1-naphthyl)ethylamine as an intermediate of cinacalcet.

Technology Process of N-(1-(naphthalen-1-yl)ethyl)forMaMide

There total 5 articles about N-(1-(naphthalen-1-yl)ethyl)forMaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (RS)-1-(1-naphthyl)ethylamine (42882-31-5) → N-formyl-1-naphthylethylamine (49681-33-6)

Guidance literature:

With 1-methyl-1H-imidazole; [2,2]bipyridinyl; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; In acetonitrile; at 60 ℃; for 20h; under 1125.11 Torr;

DOI:10.1002/cssc.201903266

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (RS)-1-(1-naphthyl)ethylamine (42882-31-5) → N-formyl-1-naphthylethylamine (49681-33-6)

Guidance literature:

With 1-methyl-1H-imidazole; [2,2]bipyridinyl; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; In acetonitrile; at 60 ℃; for 20h; under 1125.11 Torr;

DOI:10.1002/cssc.201903266

Reference yield:

1'-naphthacetophenone (941-98-0) → N-formyl-1-naphthylethylamine (49681-33-6)

Guidance literature:

upstream raw materials:

1'-naphthacetophenone

ammonium formate

methanol

(RS)-1-(1-naphthyl)ethylamine

Downstream raw materials:

(RS)-1-(1-naphthyl)ethylamine

1'-naphthacetophenone