METHYL 2-HYDROXY-4-NITROBENZOATE

Base Information

• Chemical Name: METHYL 2-HYDROXY-4-NITROBENZOATE
• CAS No.: 13684-28-1
• Molecular Formula: C8H7NO5
• Molecular Weight: 197.147
• Hs Code.: 2918290000
• Mol file: 13684-28-1.mol

Synonyms:Salicylicacid, 4-nitro-, methyl ester (7CI,8CI);2-Hydroxy-4-nitrobenzoic acid methylester;NSC 165605;

Chemical Property of METHYL 2-HYDROXY-4-NITROBENZOATE

Chemical Property:

• Vapor Pressure: 0.000129mmHg at 25°C
• Melting Point: 101-102 °C
• Refractive Index: 1.59
• Boiling Point: 324.5 °C at 760 mmHg
• PKA: 8.08±0.19(Predicted)
• Flash Point: 150.1 °C
• PSA: 92.35000
• Density: 1.432 g/cm³
• LogP: 1.61020
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

methyl2-hydroxy-4-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-HYDROXY-4-NITROBENZOATE

There total 8 articles about METHYL 2-HYDROXY-4-NITROBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-hydroxy-4-nitrobenzoic acid (619-19-2) + diazomethyl-trimethyl-silane (18107-18-1) → 2-hydroxy-4-nitro-benzoic acid methyl ester (13684-28-1)

Guidance literature:

In methanol; hexane; toluene; at 20 ℃; for 1.25h;

Reference yield: 98.0%

methanol (67-56-1) + 2-hydroxy-4-nitrobenzoic acid (619-19-2) → 2-hydroxy-4-nitro-benzoic acid methyl ester (13684-28-1)

Guidance literature:

With sulfuric acid; at 65 ℃; for 96h; Inert atmosphere;

DOI:10.1016/j.tet.2011.11.078

Reference yield: 97.0%

2-hydroxy-4-nitrobenzoic acid (619-19-2) → 2-hydroxy-4-nitro-benzoic acid methyl ester (13684-28-1)

Guidance literature:

With thionyl chloride; In methanol; at 0 ℃; for 6h; Reflux;

DOI:10.1002/chem.201300817

upstream raw materials:

diazomethane

2-hydroxy-4-nitrobenzoic acid

methanol

2-hydroxy-4-nitrobenzoyl chloride

Downstream raw materials:

methyl 2-methoxy-4-nitrobenzoate

4-nitro-2-propoxy-benzoic acid methyl ester

2-hydroxy-4-nitro-benzohydroxamic acid

2-(2-diethylamino-ethoxy)-4-nitro-benzoic acid methyl ester