b-oxo-1-Pyrrolidinepropanoic acid

Base Information

• Chemical Name: b-oxo-1-Pyrrolidinepropanoic acid
• CAS No.: 497070-73-2
• Molecular Formula: C7H11NO3
• Molecular Weight: 157.16700
• Mol file: 497070-73-2.mol

Synonyms:3-Oxo-3-pyrrolidin-1-yl-propionic acid;3-oxo-3-(1-pyrrolidinyl)propanoic acid;

Chemical Property of b-oxo-1-Pyrrolidinepropanoic acid

Chemical Property:

• Melting Point: 102 - 104 °C
• PSA: 57.61000
• LogP: 0.02140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of b-oxo-1-Pyrrolidinepropanoic acid

There total 2 articles about b-oxo-1-Pyrrolidinepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzyl 3-oxo-3-(pyrrolidin-1-yl)propanoate → 3-oxo-3-(pyrrolidin-1-yl)propionic acid (497070-73-2)

Guidance literature:

With water; sodium hydroxide;

Reference yield: 68.0%

cycl-isopropylidene malonate (2033-24-1) + N-trimethylsilylpyrrolidine (15097-49-1) → 3-oxo-3-(pyrrolidin-1-yl)propionic acid (497070-73-2)

Guidance literature:

In dichloromethane; for 2h;

DOI:10.1055/s-2002-34845

Reference yield: 72.0%

phenylacetyl chloride (103-80-0) + 3-oxo-3-(pyrrolidin-1-yl)propionic acid (497070-73-2) → N-(4-phenyl-3-oxobutanoyl)pyrrolidine

Guidance literature:

3-oxo-3-(pyrrolidin-1-yl)propionic acid; With [2,2]bipyridinyl; n-butyllithium; In tetrahydrofuran; hexane; at -78 - -10 ℃;

phenylacetyl chloride; In tetrahydrofuran; hexane; for 0.5h;

DOI:10.1055/s-2002-34845

upstream raw materials:

cycl-isopropylidene malonate

N-trimethylsilylpyrrolidine