Carbamic acid, [(1R,3S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4,4,4-trifluoro-3 -[(phenylmethoxy)methyl]butyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1R,3S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4,4,4-trifluoro-3 -[(phenylmethoxy)methyl]butyl]-, 1,1-dimethylethyl ester
CAS No.:497103-63-6
Molecular Formula:C24H40F3NO4Si
Molecular Weight:491.667
Hs Code.:

Carbamic acid,
[(1R,3S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4,4,4-trifluoro-3
-[(phenylmethoxy)methyl]butyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, [(1R,3S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4,4,4-trifluoro-3 -[(phenylmethoxy)methyl]butyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1R,3S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4,4,4-trifluoro-3 -[(phenylmethoxy)methyl]butyl]-, 1,1-dimethylethyl ester

There total 6 articles about Carbamic acid, [(1R,3S)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4,4,4-trifluoro-3 -[(phenylmethoxy)methyl]butyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 497103-70-5
(2R)-2-[N-(1,1-dimethyl)ethoxycarbonylamino]-5-benzyloxy-4-trifluoromethylpentanol

: 497103-64-7
(2R,4R)-2-[N-(1,1-dimethyl)ethoxycarbonylamino]-1-tert-butyldimethylsilyloxy-5-benzyloxy-4-trifluoromethylpentane

: 497103-63-6
(2R,4S)-2-[N-(1,1-dimethyl)ethoxycarbonylamino]-1-tert-butyldimethylsilyloxy-5-benzyloxy-4-trifluoromethylpentane

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1039/b206719f

Reference yield:

: (R)-4-((Z)-2-Ethoxycarbonyl-3,3,3-trifluoro-propenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 497103-63-6
(2R,4S)-2-[N-(1,1-dimethyl)ethoxycarbonylamino]-1-tert-butyldimethylsilyloxy-5-benzyloxy-4-trifluoromethylpentane

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Raney-Ni / aq. methanol / 20 °C

2.1: 2.30 g / LiAlH₄ / diethyl ether / 0 °C

3.1: Bu₄NI; NaH / tetrahydrofuran / 0.33 h / 0 - 20 °C

3.2: 95 percent / tetrahydrofuran / 5 h / 20 °C

4.1: 77 percent / aq. AcOH / 50 °C

5.1: 37 percent / imidazole / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; nickel; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1039/b206719f

Reference yield:

: 100-39-0
benzyl bromide

: 497103-63-6
(2R,4S)-2-[N-(1,1-dimethyl)ethoxycarbonylamino]-1-tert-butyldimethylsilyloxy-5-benzyloxy-4-trifluoromethylpentane

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bu₄NI; NaH / tetrahydrofuran / 0.33 h / 0 - 20 °C

1.2: 95 percent / tetrahydrofuran / 5 h / 20 °C

2.1: 77 percent / aq. AcOH / 50 °C

3.1: 37 percent / imidazole / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b206719f