1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-N-[4-[[(1-ethyl-1H-imidazol-2-yl)methyl]thio] phenyl]-2,3-dihydro-1-(2-methylpropyl)-

Base Information

Chemical Name:1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-N-[4-[[(1-ethyl-1H-imidazol-2-yl)methyl]thio] phenyl]-2,3-dihydro-1-(2-methylpropyl)-
CAS No.:497852-90-1
Molecular Formula:C39H48N4O3S
Molecular Weight:652.901
Hs Code.:

1H-1-Benzazepine-4-carboxamide,
7-[4-(2-butoxyethoxy)phenyl]-N-[4-[[(1-ethyl-1H-imidazol-2-yl)methyl]thio]
phenyl]-2,3-dihydro-1-(2-methylpropyl)-

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Chemical Property of 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-N-[4-[[(1-ethyl-1H-imidazol-2-yl)methyl]thio] phenyl]-2,3-dihydro-1-(2-methylpropyl)-

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Technology Process of 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-N-[4-[[(1-ethyl-1H-imidazol-2-yl)methyl]thio] phenyl]-2,3-dihydro-1-(2-methylpropyl)-

There total 5 articles about 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-N-[4-[[(1-ethyl-1H-imidazol-2-yl)methyl]thio] phenyl]-2,3-dihydro-1-(2-methylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 497853-80-2
4-{[(1-ethyl-1H-imidazol-5-yl)methyl]sulfanyl}aniline

: 313736-34-4
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

: 497852-90-1
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-ethyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

4-{[(1-ethyl-1H-imidazol-5-yl)methyl]sulfanyl}aniline; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 497853-80-2
4-{[(1-ethyl-1H-imidazol-5-yl)methyl]sulfanyl}aniline

: 597583-16-9
7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride

: 497852-90-1
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-ethyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2004.10.021

Reference yield:

: 111851-98-0
1-ethyl-2-formylimidazole

: 497852-90-1
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-ethyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 72 percent / LiAlH₄ / tetrahydrofuran / cooling

2.1: SOCl₂; DMF / CHCl₃ / 0 - 20 °C

2.2: 100 percent / NaOH / methanol; H₂O / 0 - 20 °C

3.1: Et₃N / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; chloroform;
DOI:10.1016/j.bmc.2004.10.021