N-[(3-Bromophenyl)methylene]-2,2-dimethoxyethanamine

Base Information

• Chemical Name: N-[(3-Bromophenyl)methylene]-2,2-dimethoxyethanamine
• CAS No.: 497863-61-3
• Molecular Formula: C11H14BrNO2
• Molecular Weight: 272.142
• Mol file: 497863-61-3.mol

Synonyms:1-(3-bromophenyl)-N-(2,2-dimethoxyethyl)methanimine;

Chemical Property of N-[(3-Bromophenyl)methylene]-2,2-dimethoxyethanamine

Chemical Property:

• Boiling Point: 314.0±42.0 °C(Predicted)
• PKA: 4.01±0.50(Predicted)
• PSA: 30.82000
• Density: 1.29±0.1 g/cm3(Predicted)
• LogP: 2.48690
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

N-[(3-Bromophenyl)methylene]-2,2-dimethoxyethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(3-Bromophenyl)methylene]-2,2-dimethoxyethanamine

There total 1 articles about N-[(3-Bromophenyl)methylene]-2,2-dimethoxyethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) + 2,2-dimethoxyethylamine (22483-09-6) → m-bromobenzalaminoacetal (497863-61-3)

Guidance literature:

DOI:10.1016/S0960-894X(02)00304-9

Reference yield:

m-bromobenzalaminoacetal (497863-61-3) → 5-bromoisoquinoline (34784-04-8) + 7-bromoisoquinoline (58794-09-5)

Guidance literature:

With phosphorus pentoxide; sulfuric acid; at 160 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ja902601e

Reference yield:

m-bromobenzalaminoacetal (497863-61-3) → 2-fluoro-3-isoquinolin-7-yl-but-2-enoic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide (497863-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: AlMe₃ / CH₂Cl₂

With trimethylaluminum; In dichloromethane; 2: Weinreb amidation;

DOI:10.1016/S0960-894X(02)00304-9

upstream raw materials:

m-bromobenzoic aldehyde

2,2-dimethoxyethylamine

Downstream raw materials:

2-fluoro-3-isoquinolin-7-yl-but-2-enoic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

2-fluoro-3-isoquinolin-7-yl-but-2-enoic acid (2'-tert-butylsulfamoyl-3-chloro-biphenyl-4-yl)-amide

(2E) N-{4-[(2-tert-butylaminosulfonyl)phenyl]-2-fluorophenyl}-3-(isoquinolin-7-yl)-2-fluoro-3-methylacrylamide

2-fluoro-3-isoquinolin-7-yl-but-2-enoic acid (3-bromo-2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

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