Aminoacetaldehyde dimethyl acetal

Base Information

• Chemical Name: Aminoacetaldehyde dimethyl acetal
• CAS No.: 22483-09-6
• Deprecated CAS: 1005473-07-3
• Molecular Formula: C4H11NO2
• Molecular Weight: 105.137
• Hs Code.: 29225000
• European Community (EC) Number: 245-026-5
• NSC Number: 73701
• UNII: XF4JYB7VV5
• DSSTox Substance ID: DTXSID7066803
• Nikkaji Number: J26.136J
• Wikidata: Q72467919
• Mol file: 22483-09-6.mol

Synonyms:Aminoacetaldehyde dimethyl acetal;22483-09-6;2,2-Dimethoxyethylamine;2,2-Dimethoxyethanamine;Ethanamine, 2,2-dimethoxy-;2,2-DIMETHOXYETHAN-1-AMINE;Acetaldehyde, amino-, dimethyl acetal;Glycinal Dimethyl Acetal;2,2-dimethoxy-ethylamine;XF4JYB7VV5;EINECS 245-026-5;NSC 73701;NSC-73701;MFCD00008135;amino acetaldehyde dimethyl acetal;Ethanamine,2-dimethoxy-;SCHEMBL94;UNII-XF4JYB7VV5;2, 2-Dimethoxyethanamine;(2,2-dimethoxyethyl)amine;2,2-dimethoxy-1-ethanamine;2,2-bis(methyloxy)ethanamine;N-(2,2-Dimethoxyethyl)amine;1-amino-2,2-dimethyoxyethane;aminoacetaldehyde dimethylacetal;aminoacetaldehyde-dimethylacetal;aminoacetaldehyd dimethyl acetal;aminoacetoaldehyde dimethylacetal;amino acetaldehyde dimethylacetal;amino-acetaldehyde dimethylacetal;aminoacetaldehyde dimethyl-acetal;amino acetaldhyde dimethyl acetal;DTXSID7066803;[2,2-bis(methyloxy)ethyl]amine;aminoacetoaldehyde dimethyl acetal;2-aminoacetaldehyde dimethylacetal;amino-acetaldehyde dimethyl acetal;2-amino-acetaldehyde-dimethylacetal;BCP26487;NSC73701;STR00343;2-amino acetaldehyde dimethyl acetal;2-amino-acetaldehyde dimethyl acetal;ETHYLAMINE, 2,2-DIMETHOXY-;1-AMINO-2,2-DIMETHOXYETHANE;BBL011384;STL146485;AKOS005721047;AB00930;Aminoacetaldehyde dimethyl acetal, 99%;BP-10028;2-AMINOACETALDEHYDE DIMETHYL ACETAL;A0801;CS-0015304;FT-0622278;EN300-19623;A-4900;D72504;F2190-0377;Aminoacetaldehyde dimethyl acetal (2,2-dimethoxyethylamine)

Chemical Property of Aminoacetaldehyde dimethyl acetal

Chemical Property:

• Appearance/Colour: clear colorless to pale yellow liquid
• Vapor Pressure: 8.66mmHg at 25°C
• Melting Point: -78oC
• Refractive Index: n20/D 1.417(lit.)
• Boiling Point: 133 °C at 760 mmHg
• PKA: 6.95±0.10(Predicted)
• Flash Point: 53.3 °C
• PSA: 44.48000
• Density: 0.944 g/cm³
• LogP: 0.26430
• Storage Temp.: Flammables area
• Water Solubility.: miscible
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 105.078978594
• Heavy Atom Count: 7
• Complexity: 36.7

Purity/Quality:

99% ^*data from raw suppliers

GlycinalDimethylAcetal ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,F,Xi
• Hazard Codes: C,F,Xi
• Statements: 10-34-36/37/38
• Safety Statements: 26-36/37/39-45-16-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(CN)OC
• Uses: Amino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates.

Technology Process of Aminoacetaldehyde dimethyl acetal

There total 15 articles about Aminoacetaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

chloroacetaldehyde dimethyl acetal (97-97-2) → 2,2-dimethoxyethylamine (22483-09-6)

Guidance literature:

With ammonium hydroxide; carbon dioxide; at 140 ℃; for 8h; Autoclave; Large scale;

Reference yield: 91.0%

2-(2,2-dimethoyxethyl)-1H-isoindole-1,3(2H)-dione (27328-34-3) → 2,2-dimethoxyethylamine (22483-09-6)

Guidance literature:

With ethanolamine; at 170 - 180 ℃;

DOI:10.1007/BF00831701

Reference yield: 86.0%

→ N-(2-cyanoethyl)-N-(2,2-dimethoxyethyl)-3-aminopropiononitrile + 2,2-dimethoxyethylamine (22483-09-6)

Guidance literature:

upstream raw materials:

1-bromo-2,2-dimethoxyethane

chloroacetaldehyde dimethyl acetal

dimethoxy acetonitrile

C₈H₁₇NO₂

Downstream raw materials:

(3,4,3',4'-tetramethoxy-bibenzyl-α-ylamino)-acetaldehyde dimethylacetal

N-(cyclohexyl-phenyl-methyl)-N'-(2,2-dimethoxy-ethyl)-urea

N-benzhydryl-N'-(2,2-dimethoxy-ethyl)-urea

(2,2-dimethoxy-ethyl)-(phenyl-thiazol-2-yl-methylene)-amine

Refernces

• 1、 -. "Technology for producing aminoacetaldehyde dimethyl acetal". Paragraph 0014-0016. . Retrieved 2019/08/20.
• 2、 Serradeil-Albalat, Muriel,Roussel, Christian,Vanthuyne, Nicolas,Vallejos, Jean-Claude,Wilhelm, Didier. "Synthesis of chiral primary amines: diastereoselective alkylation of N-[(1E)-alkylidene]-3,5-bis[(1S)-1-methoxyethyl]-4H-1,2,4-triazol-4-amin es and N4-Nexocyclic bond cleavage in the resulting 1,2,4-triazol-4-alkylamines". body text. p. 2682 - 2692. Retrieved 2009/04/07.