5-BROMO-2-ETHYLAMINOPYRIDINE

Base Information

• Chemical Name: 5-BROMO-2-ETHYLAMINOPYRIDINE
• CAS No.: 856850-36-7
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.066
• Hs Code.: 2933399990
• Mol file: 856850-36-7.mol

Synonyms:5-Bromo-2-ethylaminopyridine;

Chemical Property of 5-BROMO-2-ETHYLAMINOPYRIDINE

Chemical Property:

• Boiling Point: 259.055 °C at 760 mmHg
• Flash Point: 110.473 °C
• Density: 1.491 g/cm³
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-N-ethylpyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-ETHYLAMINOPYRIDINE

There total 5 articles about 5-BROMO-2-ETHYLAMINOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-(5-bromopyridin-2-yl)acetamide (7169-97-3) → 5-bromo-N-ethylpyridin-2-amine (856850-36-7)

Guidance literature:

N-(5-bromopyridin-2-yl)acetamide; With borane-THF; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere; Cooling with ice;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; for 1h; Reflux;

DOI:10.1021/acsmedchemlett.7b00222

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) + acetic acid (64-19-7,77671-22-8) → 5-bromo-N-ethylpyridin-2-amine (856850-36-7)

Guidance literature:

5-bromo-2-pyridylamine; acetic acid; In ethanol; at 0 ℃; for 2h;

With sodium cyanoborohydride; In ethanol; at 0 - 20 ℃; for 1h;

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) → 5-bromo-N-ethylpyridin-2-amine (856850-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 1 h / 60 °C

2.1: borane-THF / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: 1 h / Reflux

With borane-THF; acetic acid; In tetrahydrofuran;

DOI:10.1021/acsmedchemlett.7b00222

upstream raw materials:

5-bromo-2-pyridylamine

sodium ethanolate

N-(5-bromopyridin-2-yl)acetamide

acetic acid