2-(4-Bromomethyl-phenyl)-5-phenyl-oxazole

Base Information

Chemical Name:2-(4-Bromomethyl-phenyl)-5-phenyl-oxazole
CAS No.:49822-48-2
Molecular Formula:C16H12BrNO
Molecular Weight:314.181
Hs Code.:
DSSTox Substance ID:DTXSID40482386
Nikkaji Number:J1.371.813J

Synonyms:49822-48-2;2-(4-bromomethyl-phenyl)-5-phenyl-oxazole;Oxazole, 2-[4-(bromomethyl)phenyl]-5-phenyl-;SCHEMBL1663831;2-[4-(BROMOMETHYL)PHENYL]-5-PHENYL-1,3-OXAZOLE;DTXSID40482386;VRIQTDYXGAHRLV-UHFFFAOYSA-N;2-(4-bromomethylphenyl)-5-phenyloxazole;2-(4-bromomethyl-phenyI)-5-phenyl-oxazole

Suppliers and Price of 2-(4-Bromomethyl-phenyl)-5-phenyl-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Bromomethyl-phenyl)-5-phenyl-oxazole

Chemical Property:

PSA：26.03000
LogP:4.90350
XLogP3:5.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:313.01023
Heavy Atom Count:19
Complexity:272

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CN=C(O2)C3=CC=C(C=C3)CBr

Technology Process of 2-(4-Bromomethyl-phenyl)-5-phenyl-oxazole

There total 6 articles about 2-(4-Bromomethyl-phenyl)-5-phenyl-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 16155-60-5
5-phenyl-2-p-tolyloxazole

: 49822-48-2
4-(5-Phenyloxazole-2-yl)benzyl bromide

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 3h; Heating;
DOI:10.1007/BF00503327

Reference yield:

: 82221-14-5
4-Methyl-N-[1-(2-oxo-2-phenylethyl)]benzamide

: 49822-48-2
4-(5-Phenyloxazole-2-yl)benzyl bromide

Guidance literature:: Multi-step reaction with 2 steps

1: 83.5 percent / POCl₃ / 3 h / Heating

2: 58.6 percent / NBS; AIBN / CCl₄ / 6 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trichlorophosphate; In tetrachloromethane; 1: Cyclization / 2: Bromination;
DOI:10.1002/1521-3765(20000804)6:15<2809::AID-CHEM2809>3.0.CO;2-M

Reference yield:

: 5468-37-1
2-aminoacetophenone hydrochloride

: 49822-48-2
4-(5-Phenyloxazole-2-yl)benzyl bromide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / aq. Na₂CO₃ / 2 h / 20 °C

2: 83.5 percent / POCl₃ / 3 h / Heating

3: 58.6 percent / NBS; AIBN / CCl₄ / 6 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium carbonate; trichlorophosphate; In tetrachloromethane; 1: Acylation / 2: Cyclization / 3: Bromination;
DOI:10.1002/1521-3765(20000804)6:15<2809::AID-CHEM2809>3.0.CO;2-M