1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-
• CAS No.: 499134-60-0
• Molecular Formula: C25H25ClFN7O3
• Molecular Weight: 525.97

Synonyms:

Chemical Property of 1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-

There total 1 articles about 1H-Pyrrole-2-carboxamide, 5-[[4-[(3-chloro-4-fluorophenyl)amino]-1,6-dihydro-6-oxo-5H-pyrrolo[2,3- d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 5-(4-chloro-6-oxo-6,7-dihydro-pyrrolo[2,3-d]pyrimidin-5-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide + 3-chloro-4-fluorophenylamine (367-21-5) + diethylene glycol dimethyl ether (111-96-6) → 5-[4-(3-Chloro-4-fluoro-phenylamino)-6-oxo-6,7-dihydro-pyrrolo [2,3-d]pyrimidin-5-ylidenemethyl]-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide (499134-60-0) + 5-[4-(3-chloro-4-fluoro-phenylamino)-6-oxo-6,7-dihydro-pyrrolo [2,3-d]pyrimidin-5-ylidenemethyl]-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide hydrochloride (346599-65-3)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In hydrogenchloride;

Reference yield: 65.0%

4-(morpholinomethyl)morpholine (5625-90-1) + 5-[4-(3-Chloro-4-fluoro-phenylamino)-6-oxo-6,7-dihydro-pyrrolo [2,3-d]pyrimidin-5-ylidenemethyl]-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide (499134-60-0) → 5-[4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-7-MORPHOLIN-4-YLMETHYL-6-OXO-6,7-DIHYDRO-PYRROLO [2,3-D]PYRIMIDIN-5-YLIDENEMETHYL]-4-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID (2-MORPHOLIN-4-YL-ETHYL)-AMIDE (346600-17-7) + 5-[4-(3-chloro-4-fluoro-phenylamino)-7-morpholin-4-ylmethyl-6-oxo-6,7-dihydro-pyrrolo [2,3-d ]pyrimidinylidenemethyl]-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide

Guidance literature:

upstream raw materials:

1-methyl-pyrrolidin-2-one

3-chloro-4-fluorophenylamine

diethylene glycol dimethyl ether

Downstream raw materials:

5-[4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-7-MORPHOLIN-4-YLMETHYL-6-OXO-6,7-DIHYDRO-PYRROLO [2,3-D]PYRIMIDIN-5-YLIDENEMETHYL]-4-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID (2-MORPHOLIN-4-YL-ETHYL)-AMIDE

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