2,4-Difluoro-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 2,4-Difluoro-benzoic acid tert-butyl ester
• CAS No.: 500353-15-1
• Molecular Formula: C11H12F2O2
• Molecular Weight: 214.212
• Mol file: 500353-15-1.mol

Synonyms:Benzoic acid,2,4-difluoro-,1,1-dimethylethyl ester;2,4-difluoro-benzoic acid tert-butyl ester;

Chemical Property of 2,4-Difluoro-benzoic acid tert-butyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.92010
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluoro-benzoicAcidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Difluoro-benzoic acid tert-butyl ester

There total 3 articles about 2,4-Difluoro-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tert-butyl alcohol (75-65-0) + 2,4-difluoro-benzoic acid (1583-58-0) → tert-butyl 2,4-difluorobenzoate (500353-15-1)

Guidance literature:

With dmap; di-tert-butyl dicarbonate; for 48h;

DOI:10.1021/jo020600b

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 2,4-difluoro-benzoic acid (1583-58-0) → tert-butyl 2,4-difluorobenzoate (500353-15-1)

Guidance literature:

With dmap; In dichloromethane; tert-butyl alcohol; at 20 ℃; for 24h;

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + tert-butyl alcohol (75-65-0) + 2,4-difluoro-benzoic acid (1583-58-0) → tert-butyl 2,4-difluorobenzoate (500353-15-1)

Guidance literature:

dmap; In dichloromethane; at 20 ℃; for 24h;

upstream raw materials:

tert-butyl alcohol

2,4-difluoro-benzoic acid

di-tert-butyl dicarbonate

Downstream raw materials:

4-fluoro-2-((R)-2-methoxy-1-methyl-ethylamino)-benzoic acid tert-butyl ester

4-fluoro-2-((S)-2-methoxy-1-methyl-ethylamino)-benzoic acid tert-butyl ester

4-(4-dimethylaminocyclohexylideneaminooxy)-2-fluorobenzoic acid tert-butyl ester

C₁₆H₂₂FNO₂

Refernces

• 1、 -. "SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS". Page/Page column 74. . Retrieved 2010/08/05.
• 2、 -. "INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER". Page/Page column 74. . Retrieved 2008/12/06.