Methanesulfonic acid, trifluoro-, 3-[(2S)-3-amino-2-[[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2- hydroxy-4-phenylbutyl]amino]-3-oxopropyl]phenyl ester

Base Information

Chemical Name:Methanesulfonic acid, trifluoro-, 3-[(2S)-3-amino-2-[[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2- hydroxy-4-phenylbutyl]amino]-3-oxopropyl]phenyl ester
CAS No.:500767-18-0
Molecular Formula:C25H32F3N3O7S
Molecular Weight:575.606
Hs Code.:

Methanesulfonic acid, trifluoro-,
3-[(2S)-3-amino-2-[[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-
hydroxy-4-phenylbutyl]amino]-3-oxopropyl]phenyl ester

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Chemical Property of Methanesulfonic acid, trifluoro-, 3-[(2S)-3-amino-2-[[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2- hydroxy-4-phenylbutyl]amino]-3-oxopropyl]phenyl ester

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Technology Process of Methanesulfonic acid, trifluoro-, 3-[(2S)-3-amino-2-[[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2- hydroxy-4-phenylbutyl]amino]-3-oxopropyl]phenyl ester

There total 6 articles about Methanesulfonic acid, trifluoro-, 3-[(2S)-3-amino-2-[[(2S,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2- hydroxy-4-phenylbutyl]amino]-3-oxopropyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 500767-11-3
Trifluoro-methanesulfonic acid 3-((S)-2-amino-2-carbamoyl-ethyl)-phenyl ester

: 500767-18-0
(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-2-[m-(trifluoromethanesulfonyloxy)benzyl]heptanoyl amide

Guidance literature:: In isopropyl alcohol; Heating;
DOI:10.1021/jm020951i

Reference yield:

: 587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2
m-tyrosine

: 500767-18-0
(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-2-[m-(trifluoromethanesulfonyloxy)benzyl]heptanoyl amide

Guidance literature:: Multi-step reaction with 6 steps

1: AcCl / 20 °C

2: NH₃ / methanol / 20 °C

3: 77 percent / aq. NaHCO₃ / tetrahydrofuran / 20 °C

4: 89 percent / K₂CO₃; Et₃N / CH₂Cl₂ / 0.5 h / Heating

5: TFA / CH₂Cl₂ / 0.25 h

6: 79 percent / propan-2-ol / Heating

With ammonia; sodium hydrogencarbonate; potassium carbonate; triethylamine; acetyl chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm020951i

Reference yield:

: 167935-97-9
methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate

: 500767-18-0
(2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenyl-2-[m-(trifluoromethanesulfonyloxy)benzyl]heptanoyl amide

Guidance literature:: Multi-step reaction with 5 steps

1: NH₃ / methanol / 20 °C

2: 77 percent / aq. NaHCO₃ / tetrahydrofuran / 20 °C

3: 89 percent / K₂CO₃; Et₃N / CH₂Cl₂ / 0.5 h / Heating

4: TFA / CH₂Cl₂ / 0.25 h

5: 79 percent / propan-2-ol / Heating

With ammonia; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm020951i