2-Pyridinecarboxamide, N-[(1S)-1-[[[(1S,2S)-3-[[(1S)-2-amino-1-[(4-bromophenyl)methyl]-2-oxo ethyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]amino]carbonyl]-2-methyl propyl]-

Base Information

Chemical Name:2-Pyridinecarboxamide, N-[(1S)-1-[[[(1S,2S)-3-[[(1S)-2-amino-1-[(4-bromophenyl)methyl]-2-oxo ethyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]amino]carbonyl]-2-methyl propyl]-
CAS No.:500767-38-4
Molecular Formula:C30H36BrN5O4
Molecular Weight:610.551
Hs Code.:

2-Pyridinecarboxamide,
N-[(1S)-1-[[[(1S,2S)-3-[[(1S)-2-amino-1-[(4-bromophenyl)methyl]-2-oxo
ethyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]amino]carbonyl]-2-methyl
propyl]-

Synonyms:

Suppliers and Price of 2-Pyridinecarboxamide, N-[(1S)-1-[[[(1S,2S)-3-[[(1S)-2-amino-1-[(4-bromophenyl)methyl]-2-oxo ethyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]amino]carbonyl]-2-methyl propyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Pyridinecarboxamide, N-[(1S)-1-[[[(1S,2S)-3-[[(1S)-2-amino-1-[(4-bromophenyl)methyl]-2-oxo ethyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]amino]carbonyl]-2-methyl propyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxamide, N-[(1S)-1-[[[(1S,2S)-3-[[(1S)-2-amino-1-[(4-bromophenyl)methyl]-2-oxo ethyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]amino]carbonyl]-2-methyl propyl]-

There total 11 articles about 2-Pyridinecarboxamide, N-[(1S)-1-[[[(1S,2S)-3-[[(1S)-2-amino-1-[(4-bromophenyl)methyl]-2-oxo ethyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]amino]carbonyl]-2-methyl propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(S)-2-(4-Bromo-phenyl)-1-carbamoyl-ethyl]-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-carbamic acid benzyl ester

: 500767-38-4
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-2-(4-bromo-phenyl)-1-carbamoyl-ethylamino]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: With trifluorormethanesulfonic acid; methoxybenzene; In dichloromethane; at 20 ℃; for 0.0833333h;
DOI:10.1021/jm020951i

Reference yield:

: 98-98-6
2-Picolinic acid

: 500767-38-4
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-2-(4-bromo-phenyl)-1-carbamoyl-ethylamino]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: TBTU; DIEA / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

2: 0.112 g / anisole; triflic acid / CH₂Cl₂ / 0.08 h / 20 °C

With trifluorormethanesulfonic acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020951i

Reference yield:

: 24250-84-8
H-p-BrPhe-OH

: 500767-38-4
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-benzyl-3-[(S)-2-(4-bromo-phenyl)-1-carbamoyl-ethylamino]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 9 steps

1: AcCl / 20 °C

2: 1.96 g / NH₃ / methanol

3: 62 percent / propan-2-ol / Heating

4: 99 percent / aq. Na₂CO₃ / tetrahydrofuran / 0.5 h / 20 °C

5: HCl / ethyl acetate / 20 °C

6: 0.554 g / TBTU; DIEA / dimethylformamide / 20 °C

7: HCl / ethyl acetate / 0.25 h / 20 °C

8: TBTU; DIEA / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

9: 0.112 g / anisole; triflic acid / CH₂Cl₂ / 0.08 h / 20 °C

With hydrogenchloride; trifluorormethanesulfonic acid; ammonia; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; acetyl chloride; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020951i