1(2H)-Pyrazinecarboxylic acid, 3,4-dihydro-5-(2-methylpropyl)-4-[[5-methyl-1-(triphenylmethyl)-1H-imid azol-4-yl]methyl]-3-oxo-2-(phenylmethyl)-, phenylmethyl ester, (2S)-

Base Information

• Chemical Name: 1(2H)-Pyrazinecarboxylic acid, 3,4-dihydro-5-(2-methylpropyl)-4-[[5-methyl-1-(triphenylmethyl)-1H-imid azol-4-yl]methyl]-3-oxo-2-(phenylmethyl)-, phenylmethyl ester, (2S)-
• CAS No.: 500782-74-1
• Molecular Formula: C47H46N4O3
• Molecular Weight: 714.907
• Mol file: 500782-74-1.mol

Synonyms:

Chemical Property of 1(2H)-Pyrazinecarboxylic acid, 3,4-dihydro-5-(2-methylpropyl)-4-[[5-methyl-1-(triphenylmethyl)-1H-imid azol-4-yl]methyl]-3-oxo-2-(phenylmethyl)-, phenylmethyl ester, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1(2H)-Pyrazinecarboxylic acid, 3,4-dihydro-5-(2-methylpropyl)-4-[[5-methyl-1-(triphenylmethyl)-1H-imid azol-4-yl]methyl]-3-oxo-2-(phenylmethyl)-, phenylmethyl ester, (2S)-

There total 8 articles about 1(2H)-Pyrazinecarboxylic acid, 3,4-dihydro-5-(2-methylpropyl)-4-[[5-methyl-1-(triphenylmethyl)-1H-imid azol-4-yl]methyl]-3-oxo-2-(phenylmethyl)-, phenylmethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

C23H26N2O3 (500782-73-0) + 4-chloromethyl-5-methyl-1-tritylimidazole (106147-85-7) → C47H46N4O3 (500782-74-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 60 ℃; for 2h;

DOI:10.1039/b517572k

Reference yield:

N-Cbz-L-Phe (1161-13-3) → C47H46N4O3 (500782-74-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / DIEA; EDCI / CH₂Cl₂ / 5 h / 20 °C

2: 40 percent / DIBALH / CH₂Cl₂; toluene / 1 h / -78 °C

3: 87 percent / TFA / H₂O / 2 h / 20 °C

4: 15 percent / NaH / tetrahydrofuran / 2 h / 60 °C

With sodium hydride; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; toluene;

DOI:10.1039/b517572k

Reference yield:

Cbz-L-Phe-L-Leu-OMe (3850-45-1) → C47H46N4O3 (500782-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / DIBALH / CH₂Cl₂; toluene / 1 h / -78 °C

2: 87 percent / TFA / H₂O / 2 h / 20 °C

3: 15 percent / NaH / tetrahydrofuran / 2 h / 60 °C

With sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; toluene;

DOI:10.1039/b517572k

upstream raw materials:

C₂₃H₂₆N₂O₃

4-chloromethyl-5-methyl-1-tritylimidazole

N-Cbz-L-Phe

Cbz-L-Phe-L-Leu-OMe

Refernces