PYR-PNA

Base Information

• Chemical Name: PYR-PNA
• CAS No.: 66642-35-1
• Molecular Formula: C11H11N3O4
• Molecular Weight: 249.226
• Hs Code.: 29337900
• Mol file: 66642-35-1.mol

Synonyms:2-Pyrrolidinecarboxamide,N-(4-nitrophenyl)-5-oxo-, (S)-;L-N-(p-Nitrophenyl)-5-oxo-2-pyrrolidinecarboxamide;L-Pyroglutamic acid p-nitroanilide;L-Pyroglutamic acid p-nitrophenylamide;L-Pyroglutamyl-p-nitroaniline;

Chemical Property of PYR-PNA

Chemical Property:

• Vapor Pressure: 1.21E-15mmHg at 25°C
• Refractive Index: 1.644
• Boiling Point: 627.1 °C at 760 mmHg
• Flash Point: 333.1 °C
• PSA: 104.02000
• Density: 1.451 g/cm ³
• LogP: 1.73690
• Storage Temp.: −20°C

Purity/Quality:

98%Min ^*data from raw suppliers

L-Pyroglutamic acid 4-nitroanilide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Substrate for pyrrolidonylpeptidase.

Technology Process of PYR-PNA

There total 4 articles about PYR-PNA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-nitro-aniline (100-01-6,104810-17-5) + L-Pyroglutamic acid (98-79-3) → (S)-N-(4-nitrophenyl)-5-oxopyrrolidine-2-carboxamide (66642-35-1)

Guidance literature:

4-nitro-aniline; L-Pyroglutamic acid; With dmap; In dichloromethane; for 0.166667h;

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 14h;

DOI:10.1016/j.bmc.2018.07.041

Reference yield:

L-Pyroglutamic acid (98-79-3) → (S)-N-(4-nitrophenyl)-5-oxopyrrolidine-2-carboxamide (66642-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / -15 °C

2: tetrahydrofuran / -15 - 20 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1016/j.tetasy.2007.03.034

Reference yield:

C8H11NO5 + 4-nitro-aniline (100-01-6,104810-17-5) → (S)-N-(4-nitrophenyl)-5-oxopyrrolidine-2-carboxamide (66642-35-1)

Guidance literature:

In tetrahydrofuran; at -15 - 20 ℃;

DOI:10.1016/j.tetasy.2007.03.034

upstream raw materials:

L-glutamic acid

4-nitro-aniline

L-Pyroglutamic acid

Refernces

• 1、 Basavaiah, Deevi,Venkateswara Rao, Kalapala,Sekhara Reddy, Bhavanam. "Chiral diamides as efficient catalytic precursors for the borane-mediated asymmetric reduction of prochiral ketones". . p. 968 - 974. Retrieved 2008/02/03.