4-(2-Bromo-5-chlorophenyl)sulfonylmorpholine

Base Information

Chemical Name:4-(2-Bromo-5-chlorophenyl)sulfonylmorpholine
CAS No.:5510-10-1
Molecular Formula:C10H11BrClNO3S
Molecular Weight:211.241
Hs Code.:
DSSTox Substance ID:DTXSID10357890
Wikidata:Q82138067
ChEMBL ID:CHEMBL1366245

Synonyms:SMR000111418;4-(2-bromo-5-chlorophenyl)sulfonylmorpholine;Cambridge id 5510101;MLS000107045;MLS002539780;CHEMBL1366245;DTXSID10357890;HMS2482N04;AB00087091-01;SR-01000407620;SR-01000407620-1

Suppliers and Price of 4-(2-Bromo-5-chlorophenyl)sulfonylmorpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-(2-Bromo-5-chlorophenyl)sulfonylmorpholine

Chemical Property:

Vapor Pressure:1.84E-08mmHg at 25°C
Boiling Point:454.9°C at 760 mmHg
Flash Point:228.9°C
PSA：54.99000
Density:1.67g/cm³
LogP:3.14210
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:338.93315
Heavy Atom Count:17
Complexity:353

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1S(=O)(=O)C2=C(C=CC(=C2)Cl)Br

Technology Process of 4-(2-Bromo-5-chlorophenyl)sulfonylmorpholine

There total 11 articles about 4-(2-Bromo-5-chlorophenyl)sulfonylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 35511-15-0
methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

: 5510-10-1
2-methyl-2H-1,2-benzothiazine-4-(3H)-one-1,1-dioxyde

Guidance literature:: With lithium iodide; In N,N-dimethyl-formamide; at 125 ℃; for 1h;
DOI:10.1002/jhet.5570270260

Reference yield: 66.0%

: 5510-09-8
1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[e][1,2]thiazin-4-one

: 74-88-4
methyl iodide

: 5510-10-1
2-methyl-2H-1,2-benzothiazine-4-(3H)-one-1,1-dioxyde

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2015.11.032

Reference yield:

: 6639-62-9
methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

: 5510-10-1
2-methyl-2H-1,2-benzothiazine-4-(3H)-one-1,1-dioxyde

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 0.5 h / 55 °C / Inert atmosphere

2: hydrogenchloride / water / 8 h / Inert atmosphere; Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With hydrogenchloride; sodium methylate; caesium carbonate; In methanol; water; N,N-dimethyl-formamide; 1: |Gabriel-Colman Rearrangement;
DOI:10.1016/j.bmc.2015.11.032