1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl] carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-

Base Information

Chemical Name:1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl] carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-
CAS No.:501666-85-9
Molecular Formula:C₃₅H₃₀ClN₅O₄S₂
Molecular Weight:684.239
Hs Code.:

1H-Indole-2-carboxamide,
N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl]
carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-

Synonyms:

Suppliers and Price of 1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl] carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl] carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl] carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]-

There total 17 articles about 1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl] carbonyl]-1H-indol-5-yl]-5-[[3-(methyldithio)-1-oxopropyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 501440-94-4
5-[5-(3-(methyldithio)propionyl)indol-2-yl-carbonylamino]indole-2-carboxylic acid

: 5-hydroxy-(1S)-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole hydrochloride

: 501666-85-9
1-(1S)-(chloromethyl)-5-hydroxy-3-{5-[(5-(3-(acetylthio)propionyl)indol-2-ylcarbonyl)amino]indole-2-carbonyl}-1,2-dihydro-3H-benz[e]indole

Guidance literature:: In N,N-dimethyl acetamide; 1,2-dichloro-ethane; Inert atmosphere;
DOI:10.1021/jm201284m

Reference yield: 63.0%

: 615538-51-7
C₃₁H₂₄ClN₅O₃

: 138148-59-1
3-Methyldisulfanyl-propionic acid

: 501666-85-9
1-(1S)-(chloromethyl)-5-hydroxy-3-{5-[(5-(3-(acetylthio)propionyl)indol-2-ylcarbonyl)amino]indole-2-carbonyl}-1,2-dihydro-3H-benz[e]indole

Guidance literature:: In N,N-dimethyl acetamide; 1,2-dichloro-ethane; Inert atmosphere;
DOI:10.1021/jm201284m

Reference yield:

: 16732-57-3
5-nitro-indole-2-carboxylic acid ethyl ester

: 501666-85-9
1-(1S)-(chloromethyl)-5-hydroxy-3-{5-[(5-(3-(acetylthio)propionyl)indol-2-ylcarbonyl)amino]indole-2-carbonyl}-1,2-dihydro-3H-benz[e]indole

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2068.65 Torr

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / Inert atmosphere

3.1: sodium hydroxide / N,N-dimethyl acetamide; water / 1 h

3.2: pH 3

4.1: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere

5.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / N,N-dimethyl acetamide

6.1: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; 1,2-dichloro-ethane;
DOI:10.1021/jm201284m