1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole

Base Information

Chemical Name:1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole
CAS No.:615538-49-3
Molecular Formula:C₄₉H₄₃ClN₅O₇PS₂
Molecular Weight:944.468
Hs Code.:

1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole

Synonyms:

Suppliers and Price of 1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole

There total 18 articles about 1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 501666-85-9
1-(1S)-(chloromethyl)-5-hydroxy-3-{5-[(5-(3-(acetylthio)propionyl)indol-2-ylcarbonyl)amino]indole-2-carbonyl}-1,2-dihydro-3H-benz[e]indole

: 17176-77-1
Dibenzyl phosphite

: 615538-49-3
1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; acetonitrile; Inert atmosphere;
DOI:10.1021/jm201284m

Reference yield:

: 16732-57-3
5-nitro-indole-2-carboxylic acid ethyl ester

: 615538-49-3
1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 2068.65 Torr

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / Inert atmosphere

3.1: sodium hydroxide / N,N-dimethyl acetamide; water / 1 h

3.2: pH 3

4.1: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere

5.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / N,N-dimethyl acetamide

6.1: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere

7.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; tetrachloromethane; acetonitrile / Inert atmosphere

With hydrogenchloride; dmap; palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl acetamide; water; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm201284m

Reference yield:

: 16730-20-4
5-nitro-1H-indole-2-carboxylic acid

: 615538-49-3
1-(S)-(chloromethyl)-5-dibenzylphosphonoxy-3-{{5-[5-(3-methyldithiopropionyl)indol-2-ylcarbonylamino]indole-2-yl}-carbonyl}-1,2-dihydro-3H-benz[e]indole

Guidance literature:: Multi-step reaction with 9 steps

1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 0.67 h / Inert atmosphere

2: tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2585.81 Torr

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / N,N-dimethyl acetamide / 2068.65 Torr

6: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere

7: triethylsilane; trifluoroacetic acid / dichloromethane / 0.5 h

8: N,N-dimethyl acetamide; 1,2-dichloro-ethane / Inert atmosphere

9: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; tetrachloromethane; acetonitrile / Inert atmosphere

With triethylsilane; dmap; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl acetamide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm201284m