Carbamic acid, [(1R)-2-[[(2,4-dimethoxyphenyl)methoxy]amino]-1-(hydroxymethyl)-2-oxo ethyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1R)-2-[[(2,4-dimethoxyphenyl)methoxy]amino]-1-(hydroxymethyl)-2-oxo ethyl]-, 1,1-dimethylethyl ester
• CAS No.: 501701-41-3
• Molecular Formula: C17H26N2O7
• Molecular Weight: 370.403
• Mol file: 501701-41-3.mol

Synonyms:

Chemical Property of Carbamic acid, [(1R)-2-[[(2,4-dimethoxyphenyl)methoxy]amino]-1-(hydroxymethyl)-2-oxo ethyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1R)-2-[[(2,4-dimethoxyphenyl)methoxy]amino]-1-(hydroxymethyl)-2-oxo ethyl]-, 1,1-dimethylethyl ester

There total 3 articles about Carbamic acid, [(1R)-2-[[(2,4-dimethoxyphenyl)methoxy]amino]-1-(hydroxymethyl)-2-oxo ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(R)-N-tert-butoxycarbonyl serine (3262-72-4,3850-40-6,6368-20-3,90582-28-8,84311-18-2) + O-(2,4-dimethoxy-benzyl)-hydroxylamine (216067-66-2) → [-(2,4-dimethoxybenzyloxycarbamoyl)-2-hydroxy-ethyl]carbamic acid tert-butyl ester (501701-41-3)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1021/ja0209114

Reference yield:

2,4-dimethoxylbenzyl alcohol (7314-44-5) → [-(2,4-dimethoxybenzyloxycarbamoyl)-2-hydroxy-ethyl]carbamic acid tert-butyl ester (501701-41-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / Bu₃P; DEAD / CH₂Cl₂ / 24 h / 20 °C

2: 17 g / CH₃NHNH₂ / ethanol / 1 h / Heating

3: 64 percent / EDC / CH₂Cl₂

With tributylphosphine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; methylhydrazine; diethylazodicarboxylate; In ethanol; dichloromethane;

DOI:10.1021/ja0209114

Reference yield:

N-[(2,4-Dimethoxyphenyl)methyl]phthalimide (216067-79-7) → [-(2,4-dimethoxybenzyloxycarbamoyl)-2-hydroxy-ethyl]carbamic acid tert-butyl ester (501701-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 17 g / CH₃NHNH₂ / ethanol / 1 h / Heating

2: 64 percent / EDC / CH₂Cl₂

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; methylhydrazine; In ethanol; dichloromethane;

DOI:10.1021/ja0209114

upstream raw materials:

(R)-N-tert-butoxycarbonyl serine

O-(2,4-dimethoxy-benzyl)-hydroxylamine

2,4-dimethoxylbenzyl alcohol

N-[(2,4-Dimethoxyphenyl)methyl]phthalimide