N-[(2,4-Dimethoxyphenyl)methyl]phthalimide

Base Information

• Chemical Name: N-[(2,4-Dimethoxyphenyl)methyl]phthalimide
• CAS No.: 216067-79-7
• Molecular Formula: C₁₇H₁₅NO₅
• Molecular Weight: 313.31
• Mol file: 216067-79-7.mol

Synonyms:N-[(2,4-Dimethoxyphenyl)methyl]phthalimide

Chemical Property of N-[(2,4-Dimethoxyphenyl)methyl]phthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2,4-Dimethoxyphenyl)methyl]phthalimide

There total 1 articles about N-[(2,4-Dimethoxyphenyl)methyl]phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-hydroxyphthalimide (524-38-9) + 2,4-dimethoxylbenzyl alcohol (7314-44-5) → N-[(2,4-Dimethoxyphenyl)methyl]phthalimide (216067-79-7)

Guidance literature:

With tributylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/ja0209114

Reference yield: 95.0%

N-[(2,4-Dimethoxyphenyl)methyl]phthalimide (216067-79-7) → O-(2,4-dimethoxy-benzyl)-hydroxylamine (216067-66-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.25h; Heating;

DOI:10.1016/S0040-4039(98)01760-2

Reference yield:

N-[(2,4-Dimethoxyphenyl)methyl]phthalimide (216067-79-7) → (R)-2-((E)-Styryl)-4,5-dihydro-oxazole-4-carboxylic acid (2,4-dimethoxy-benzyloxy)-amide

Guidance literature:

Multi-step reaction with 5 steps

1.1: 17 g / CH₃NHNH₂ / ethanol / 1 h / Heating

2.1: 64 percent / EDC / CH₂Cl₂

3.1: 2,6-lutidine; Me₃SiOTf / CH₂Cl₂ / 1.5 h / 0 - 20 °C

3.2: 76 percent / MeOH; Et₃N

4.1: Et₃N / pyridine / 0.17 h

5.1: polystyrene tosyl chloride resin; pyridine / 24 h / -15 °C

5.2: Et₃N; pyridine

With pyridine; 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; polystyrene tosyl chloride resin; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; methylhydrazine; In pyridine; ethanol; dichloromethane;

DOI:10.1021/ja0209114

upstream raw materials:

N-hydroxyphthalimide

2,4-dimethoxylbenzyl alcohol

Downstream raw materials:

O-(2,4-dimethoxy-benzyl)-hydroxylamine

N-((2,4-dimethoxybenzyloxycarbamoyl)methyl)-N-(4-nitrobenzyl)aminoacetic acid

N-((2,4-dimethoxybenzyloxycarbamoyl)methyl)-N-((pyridin-2-yl)methyl)aminoacetic acid

2-amino-N-(2,4-dimethoxybenzyloxy)-3-hydroxypropionamide